PMID- 23049645 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20121011 LR - 20211021 IS - 1864-6166 (Electronic) IS - 1864-6158 (Print) IS - 1864-6158 (Linking) VI - 5 IP - 1 DP - 2012 Jan TI - Effect of novel synthetic evodiamine analogue on sexual behavior in male rats. PG - 35-42 LID - 10.1007/s12154-011-0067-5 [doi] AB - Currently phosphodiestrase5 (PDE5) inhibitors are the first-line treatment for erectile dysfunction. Drugs such as sildenafil and tadalafil are available as PDE5 inhibitors which are potent and reversible but lack selectivity with side effects such as headache, facial flushing, dyspepsia, and visual disturbances. We herein report for the first time novel condensed thienopyrimidines as evodiamine analogue and their effect on sexual behavior in male rats hitherto unreported. Novel synthetic evodiamine significantly showed improvement in male rat copulatory behavior. The test compound MKAC9 could be of promising importance in the treatment of sexual disorders like desire disorder or erectile dysfunction.FigureEvodiamine analogue on sexual behavior in male rats. FAU - Vyawahare, Neeraj S AU - Vyawahare NS AD - Department of Pharmacology, AISSMS College of Pharmacy, Kennedy Road, Near R.T.O, Pune, 411 001 India. FAU - Hadambar, Avinash A AU - Hadambar AA FAU - Chothe, Aparna S AU - Chothe AS FAU - Jalnapurkar, Rajeshwar R AU - Jalnapurkar RR FAU - Bhandare, Amol M AU - Bhandare AM FAU - Kathiravan, Muthu K AU - Kathiravan MK LA - eng PT - Journal Article DEP - 20111004 PL - Germany TA - J Chem Biol JT - Journal of chemical biology JID - 101318662 PMC - PMC3251647 OTO - NOTNLM OT - Aphrodisiac OT - Evodiamine OT - PDE5 inhibitors OT - Thienopyrimidine derivative EDAT- 2012/10/11 06:00 MHDA- 2012/10/11 06:01 PMCR- 2012/10/04 CRDT- 2012/10/11 06:00 PHST- 2011/05/02 00:00 [received] PHST- 2011/09/12 00:00 [accepted] PHST- 2012/10/11 06:00 [entrez] PHST- 2012/10/11 06:00 [pubmed] PHST- 2012/10/11 06:01 [medline] PHST- 2012/10/04 00:00 [pmc-release] AID - 67 [pii] AID - 10.1007/s12154-011-0067-5 [doi] PST - ppublish SO - J Chem Biol. 2012 Jan;5(1):35-42. doi: 10.1007/s12154-011-0067-5. Epub 2011 Oct 4.