PMID- 23050055
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121011
LR  - 20211021
IS  - 1948-1756 (Electronic)
IS  - 1948-1756 (Linking)
VI  - 3
IP  - 3
DP  - 2012
TI  - GDNF and BDNF gene interplay in chronic tinnitus.
PG  - 245-51
AB  - BACKGROUND: Glial cell-derived neurotrophic factor (GDNF) and brain-derived 
      neurotrophic factor (BDNF) play key roles in the early development of the central 
      auditory pathway and the inner ear. Both have been successfully employed to treat 
      experimental forms of hearing loss and are likely to operate in a broad spectrum 
      of auditory phenotypes, including phantom perceptions of sound. We conducted a 
      genetic association study addressing five biallelic candidate variants in 240 
      Caucasian subjects who had been diagnosed with tinnitus for more than 6 months. 
      FINDINGS: Allele frequencies were determined for three GDNF and two BDNF markers, 
      including a functional missense substitution (V66M). When data were compared to 
      previously examined control populations, no significant allelic associations were 
      noted after corrections for multiple testing. However, using a multiple 
      regression approach and scores from a validated self-report questionnaire, GDNF 
      and BDNF genotypes jointly predicted tinnitus severity in women (N=69, 
      uncorrected p=0.04) but not in men (N=171, n.s.). CONCLUSIONS: The present 
      findings serve as an incentive for further explorations of neurotrophic factors' 
      role in predicting clinical features of tinnitus. Possible implications of 
      sexually dimorphic at-risk genotypes are discussed with regard to hearing and 
      neural plasticity.
FAU - Pg, Sand
AU  - Pg S
AD  - Department of Psychiatry, University of Regensburg Germany.
FAU - B, Langguth
AU  - B L
FAU - M, Schecklmann
AU  - M S
FAU - T, Kleinjung
AU  - T K
LA  - eng
PT  - Journal Article
DEP - 20120831
PL  - United States
TA  - Int J Mol Epidemiol Genet
JT  - International journal of molecular epidemiology and genetics
JID - 101525762
PMC - PMC3459214
OTO - NOTNLM
OT  - BDNF
OT  - GDNF
OT  - genetic variation
OT  - sexual dimorphism
OT  - tinnitus
EDAT- 2012/10/11 06:00
MHDA- 2012/10/11 06:01
PMCR- 2012/08/31
CRDT- 2012/10/11 06:00
PHST- 2012/07/23 00:00 [received]
PHST- 2012/08/19 00:00 [accepted]
PHST- 2012/10/11 06:00 [entrez]
PHST- 2012/10/11 06:00 [pubmed]
PHST- 2012/10/11 06:01 [medline]
PHST- 2012/08/31 00:00 [pmc-release]
PST - ppublish
SO  - Int J Mol Epidemiol Genet. 2012;3(3):245-51. Epub 2012 Aug 31.