PMID- 23050663
OWN - NLM
STAT- MEDLINE
DCOM- 20130419
LR  - 20220408
IS  - 1742-2094 (Electronic)
IS  - 1742-2094 (Linking)
VI  - 9
DP  - 2012 Oct 10
TI  - Polymorphism of tumor necrosis factor alpha (TNF-alpha) gene promoter, 
      circulating TNF-alpha level, and cardiovascular risk factor for ischemic stroke.
PG  - 235
LID - 10.1186/1742-2094-9-235 [doi]
AB  - BACKGROUND: Tumor necrosis factor-alpha (TNF-alpha) is one of the most typical 
      pro-inflammatory cytokines with both beneficial and destructive properties for 
      the central nervous system. Increasing evidences have demonstrated the important 
      role of TNF-alpha in the development of ischemic stroke, but studies examining the 
      possible association with stroke or direct functional effects of polymorphisms in 
      TNF-alpha have been contradictory. FINDINGS: In this study, a 2-kb length of the 
      proximal promoter of the TNF-alpha was screened and four polymorphisms were 
      investigated in the case-control study. Our data confirmed the association 
      between -308G/A variant with stroke in 1,388 stroke patients and 1,027 controls 
      and replicated in an independent population of 961 stroke patients and 821 
      controls (odds ratio (OR) = 1.34, 95% confidence interval (CI) =1.02 to 1.77 and 
      OR = 1.56, 95% CI = 1.09 to 2.23, respectively). To reconcile the association 
      between polymorphisms and stroke and to give a comprehensive picture of the 
      genetic architecture of this important gene, we performed a meta-analysis of 15 
      published studies in an Asian population. Our results demonstrated an association 
      between rs1800629 and ischemic stroke (OR = 1.43, 95% CI = 1.21 to 1.69). Another 
      meta-analysis results of 14 studies demonstrated that ischemic stroke patients 
      have higher serum TNF-alpha level than the control subjects (standardized mean 
      difference (SMD) = 2.33, 95% CI = 1.85 to 2.81). In vitro evaluation of potential 
      interaction between variants of the TNF-alpha gene (-308G/A, -857C/T, and -1031T/C) 
      demonstrated that these three polymorphisms could interact together to determine 
      the overall activity of the TNF-alpha gene. CONCLUSIONS: These findings strongly 
      implicate the involvement of TNF-alpha in the pathogenesis of stroke.
FAU - Cui, Guanglin
AU  - Cui G
AD  - Departments of Internal Medicine and Institute of Hypertension, Tongji Hospital, 
      Tongji Medical College, Huazhong University of Science & Technology, 1095# 
      Jiefang Ave, Wuhan, 430030, China.
FAU - Wang, Haoran
AU  - Wang H
FAU - Li, Rui
AU  - Li R
FAU - Zhang, Lina
AU  - Zhang L
FAU - Li, Zongzhe
AU  - Li Z
FAU - Wang, Yan
AU  - Wang Y
FAU - Hui, Rutai
AU  - Hui R
FAU - Ding, Hu
AU  - Ding H
FAU - Wang, Dao Wen
AU  - Wang DW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121010
PL  - England
TA  - J Neuroinflammation
JT  - Journal of neuroinflammation
JID - 101222974
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Case-Control Studies
MH  - Cell Line, Transformed
MH  - Cohort Studies
MH  - Female
MH  - Gene Frequency
MH  - Genetic Linkage
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Ischemia/complications
MH  - Male
MH  - Meta-Analysis as Topic
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Promoter Regions, Genetic/*genetics
MH  - Risk Factors
MH  - Stroke/blood/epidemiology/etiology/*genetics
MH  - Transfection
MH  - Tumor Necrosis Factor-alpha/*blood/*genetics
PMC - PMC3521196
EDAT- 2012/10/12 06:00
MHDA- 2013/04/23 06:00
PMCR- 2012/10/10
CRDT- 2012/10/12 06:00
PHST- 2012/06/21 00:00 [received]
PHST- 2012/10/03 00:00 [accepted]
PHST- 2012/10/12 06:00 [entrez]
PHST- 2012/10/12 06:00 [pubmed]
PHST- 2013/04/23 06:00 [medline]
PHST- 2012/10/10 00:00 [pmc-release]
AID - 1742-2094-9-235 [pii]
AID - 10.1186/1742-2094-9-235 [doi]
PST - epublish
SO  - J Neuroinflammation. 2012 Oct 10;9:235. doi: 10.1186/1742-2094-9-235.