PMID- 23051939
OWN - NLM
STAT- MEDLINE
DCOM- 20140501
LR  - 20191210
IS  - 1873-7862 (Electronic)
IS  - 0924-977X (Linking)
VI  - 23
IP  - 9
DP  - 2013 Sep
TI  - Behavioural and neurochemical comparison of chronic intermittent cathinone, 
      mephedrone and MDMA administration to the rat.
PG  - 1085-95
LID - S0924-977X(12)00269-6 [pii]
LID - 10.1016/j.euroneuro.2012.09.005 [doi]
AB  - The synthetic cathinone derivative, mephedrone, is a controlled substance across 
      Europe. Its effects have been compared by users to 
      3,4-methylenedioxymethamphetamine (MDMA), but little data exist on its 
      pharmacological properties. This study compared the behavioural and neurochemical 
      effects of mephedrone with cathinone and MDMA in rats. Young-adult male Lister 
      hooded rats received i.p. cathinone (1 or 4 mg/kg), mephedrone (1, 4 or 10mg/kg) 
      or MDMA (10mg/kg) on two consecutive days weekly for 3 weeks or as a single acute 
      injection (for neurochemical analysis). Locomotor activity (LMA), novel object 
      discrimination (NOD), conditioned emotional response (CER) and prepulse 
      inhibition of the acoustic startle response (PPI) were measured following 
      intermittent drug administration. Dopamine, 5-hydroxytryptamine (5-HT) and their 
      major metabolites were measured in striatum, frontal cortex and hippocampus by 
      high performance liquid chromatography 7 days after intermittent dosing and 2h 
      after acute injection. Cathinone (1, 4 mg/kg), mephedrone (10mg/kg) and MDMA 
      (10mg/kg) induced hyperactivity following the first and sixth injections and 
      sensitization to cathinone and mephedrone occurred with chronic dosing. All drugs 
      impaired NOD and mephedrone (10mg/kg) reduced freezing in response to contextual 
      re-exposure during the CER retention trial. Acute MDMA reduced hippocampal 5-HT 
      and 5-HIAA but the only significant effect on dopamine, 5-HT and their 
      metabolites following chronic dosing was altered hippocampal 
      3,4-dihydroxyphenylacetic acid (DOPAC), following mephedrone (4, 10mg/kg) and 
      MDMA. At the doses examined, mephedrone, cathinone, and MDMA induced similar 
      effects on behaviour and failed to induce neurotoxic damage when administered 
      intermittently over 3 weeks.
CI  - Copyright (c) 2012 Elsevier B.V. and ECNP. All rights reserved.
FAU - Shortall, Sinead E
AU  - Shortall SE
AD  - School of Biomedical Sciences, University of Nottingham Medical School, Queen's 
      Medical Centre, Nottingham NG7 2UH, UK.
FAU - Macerola, Alice E
AU  - Macerola AE
FAU - Swaby, Rabbi T R
AU  - Swaby RT
FAU - Jayson, Rebecca
AU  - Jayson R
FAU - Korsah, Chantal
AU  - Korsah C
FAU - Pillidge, Katharine E
AU  - Pillidge KE
FAU - Wigmore, Peter M
AU  - Wigmore PM
FAU - Ebling, Francis J P
AU  - Ebling FJ
FAU - Richard Green, A
AU  - Richard Green A
FAU - Fone, Kevin C F
AU  - Fone KC
FAU - King, Madeleine V
AU  - King MV
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121007
PL  - Netherlands
TA  - Eur Neuropsychopharmacol
JT  - European neuropsychopharmacology : the journal of the European College of 
      Neuropsychopharmacology
JID - 9111390
RN  - 0 (Alkaloids)
RN  - 44RAL3456C (Methamphetamine)
RN  - 540EI4406J (cathinone)
RN  - 8BA8T27317 (mephedrone)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Alkaloids/*administration & dosage
MH  - Animals
MH  - Brain/drug effects/*metabolism
MH  - Conditioning, Psychological/*drug effects/physiology
MH  - Dose-Response Relationship, Drug
MH  - Drug Administration Schedule
MH  - Male
MH  - Methamphetamine/administration & dosage/*analogs & derivatives
MH  - Motor Activity/*drug effects/physiology
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*administration & dosage
MH  - Random Allocation
MH  - Rats
OTO - NOTNLM
OT  - 5-HT
OT  - Cathinone
OT  - Dopamine
OT  - Locomotion
OT  - MDMA
OT  - Mephedrone
EDAT- 2012/10/12 06:00
MHDA- 2014/05/03 06:00
CRDT- 2012/10/12 06:00
PHST- 2012/06/01 00:00 [received]
PHST- 2012/08/10 00:00 [revised]
PHST- 2012/09/13 00:00 [accepted]
PHST- 2012/10/12 06:00 [entrez]
PHST- 2012/10/12 06:00 [pubmed]
PHST- 2014/05/03 06:00 [medline]
AID - S0924-977X(12)00269-6 [pii]
AID - 10.1016/j.euroneuro.2012.09.005 [doi]
PST - ppublish
SO  - Eur Neuropsychopharmacol. 2013 Sep;23(9):1085-95. doi: 
      10.1016/j.euroneuro.2012.09.005. Epub 2012 Oct 7.