PMID- 23052543
OWN - NLM
STAT- MEDLINE
DCOM- 20130523
LR  - 20171116
IS  - 1663-2826 (Electronic)
IS  - 1663-2818 (Linking)
VI  - 78
IP  - 3
DP  - 2012
TI  - Oxidative stress in obesity and metabolic syndrome in children and adolescents.
PG  - 158-64
LID - 10.1159/000342642 [doi]
AB  - BACKGROUND/AIMS: The aim of this study was to investigate the alterations in the 
      oxidant/antioxidant status in obese children with and without metabolic syndrome 
      (MetS). METHODS: We recruited 25 Caucasian obese children with MetS, 30 Caucasian 
      children with simple obesity and a control group of 30 Caucasian children. We 
      performed diacron-reactive oxygen metabolites (d-ROMs) test and biological 
      antioxidant potential (BAP) test in order to evaluate the oxidant-antioxidant 
      status in recruited patients. RESULTS: d-ROM level was significantly higher in 
      obese children with and without MetS (p = 0.005). The total antioxidant capacity 
      (BAP level) was reduced in MetS and noMetS children compared to controls (p = 
      0.009). The subjects without MetS had higher d-ROMs test and lower BAP/d-ROMs 
      ratio than subjects with MetS (although not significant). The ratio BAP/d-ROMs 
      was higher in controls than noMetS and MetS children (p < 0.0001). d-ROM level 
      was higher in prepubertal subjects with MetS than pubertal ones (p = 0.03). A 
      direct correlation was found between d-ROM levels and BMI SDS (p = 0.0005), while 
      an inverse correlation was found between BAP and BMI SDS (p = 0.004) and 
      BAP/d-ROMs and BMI SDS (p = 0.0001). CONCLUSIONS: This result confirms that fat 
      accumulation plays a key role in the pathogenesis of systemic oxidative stress 
      already during pediatric age.
CI  - Copyright (c) 2012 S. Karger AG, Basel.
FAU - Faienza, Maria Felicia
AU  - Faienza MF
AD  - Department of Biomedical Sciences and Human Oncology, University of Bari 'A. 
      Moro', Bari, Italy.
FAU - Francavilla, Ruggiero
AU  - Francavilla R
FAU - Goffredo, Rocco
AU  - Goffredo R
FAU - Ventura, Annamaria
AU  - Ventura A
FAU - Marzano, Flaviana
AU  - Marzano F
FAU - Panzarino, Gianvito
AU  - Panzarino G
FAU - Marinelli, Grazia
AU  - Marinelli G
FAU - Cavallo, Luciano
AU  - Cavallo L
FAU - Di Bitonto, Giovanna
AU  - Di Bitonto G
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20121010
PL  - Switzerland
TA  - Horm Res Paediatr
JT  - Hormone research in paediatrics
JID - 101525157
RN  - 0 (Antioxidants)
RN  - 0 (Reactive Oxygen Species)
SB  - IM
MH  - Adolescent
MH  - Antioxidants/*metabolism
MH  - Child
MH  - Female
MH  - Humans
MH  - Male
MH  - Metabolic Syndrome/*blood
MH  - Obesity/*blood
MH  - *Oxidative Stress
MH  - Reactive Oxygen Species/*blood
EDAT- 2012/10/12 06:00
MHDA- 2013/05/25 06:00
CRDT- 2012/10/12 06:00
PHST- 2012/03/26 00:00 [received]
PHST- 2012/08/11 00:00 [accepted]
PHST- 2012/10/12 06:00 [entrez]
PHST- 2012/10/12 06:00 [pubmed]
PHST- 2013/05/25 06:00 [medline]
AID - 000342642 [pii]
AID - 10.1159/000342642 [doi]
PST - ppublish
SO  - Horm Res Paediatr. 2012;78(3):158-64. doi: 10.1159/000342642. Epub 2012 Oct 10.