PMID- 23054066
OWN - NLM
STAT- MEDLINE
DCOM- 20130903
LR  - 20131121
IS  - 1461-7285 (Electronic)
IS  - 0269-8811 (Linking)
VI  - 27
IP  - 1
DP  - 2013 Jan
TI  - Parallel changes in serotonin levels in brain and blood following acute 
      administration of MDMA.
PG  - 109-12
LID - 10.1177/0269881112463123 [doi]
AB  - Recent studies have demonstrated a similar acute effect of 3,4- 
      methylenedioxymethamphetamine (MDMA) in blood platelets and brain tissue via 
      action on the serotonin transporter. To investigate the validity of blood 
      serotonin as a peripheral marker for central serotonin in this regard, we 
      administered MDMA (20 mg/kg i.p.) to rats and observed a parallel decrease in 
      serotonin levels in the frontal cortex and blood at 2 h (63% and 46% 
      respectively) with some recovery evident at 8 h (42% and 38%) and more so at 18 h 
      (19% and 24% below control levels). Administration of a tryptophan supplement 
      (82.5 mg/kg p.o.) to naive rats produced parallel increases in serotonin levels 2 
      h later in the frontal cortex (39%) and blood (26%). Following MDMA 
      administration, the same dose of tryptophan caused a smaller (26%) rise in brain 
      serotonin whereas in blood it had no effect. We conclude that blood serotonin is 
      a useful marker for brain serotonin levels in the rat following acute 
      administration of MDMA and this finding highlights the possible use of platelet 
      serotonin as a marker for brain serotonin in human studies involving MDMA.
FAU - Collins, Cheryl M
AU  - Collins CM
AD  - Leicester School of Pharmacy, De Montfort University, Leicester, UK.
FAU - Kloek, Joris
AU  - Kloek J
FAU - Elliott, J Martin
AU  - Elliott JM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121010
PL  - United States
TA  - J Psychopharmacol
JT  - Journal of psychopharmacology (Oxford, England)
JID - 8907828
RN  - 0 (Serotonin Plasma Membrane Transport Proteins)
RN  - 333DO1RDJY (Serotonin)
RN  - 8DUH1N11BX (Tryptophan)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Brain/*drug effects/*metabolism
MH  - Frontal Lobe/drug effects/metabolism
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Serotonin/*blood/*metabolism
MH  - Serotonin Plasma Membrane Transport Proteins/metabolism
MH  - Tryptophan/pharmacology
EDAT- 2012/10/12 06:00
MHDA- 2013/09/04 06:00
CRDT- 2012/10/12 06:00
PHST- 2012/10/12 06:00 [entrez]
PHST- 2012/10/12 06:00 [pubmed]
PHST- 2013/09/04 06:00 [medline]
AID - 0269881112463123 [pii]
AID - 10.1177/0269881112463123 [doi]
PST - ppublish
SO  - J Psychopharmacol. 2013 Jan;27(1):109-12. doi: 10.1177/0269881112463123. Epub 
      2012 Oct 10.