PMID- 23054634
OWN - NLM
STAT- MEDLINE
DCOM- 20130326
LR  - 20211021
IS  - 1995-8218 (Electronic)
IS  - 1673-7067 (Print)
IS  - 1995-8218 (Linking)
VI  - 28
IP  - 5
DP  - 2012 Oct
TI  - Combined action of MK-801 and ceftriaxone impairs the acquisition and 
      reinstatement of morphine-induced conditioned place preference, and delays 
      morphine extinction in rats.
PG  - 567-76
LID - 10.1007/s12264-012-1269-8 [doi]
AB  - OBJECTIVE: It is well established that glutamate and its receptors, particularly 
      the N-methyl-D-aspartate receptor (NMDAR), play a significant role in addiction 
      and that the inhibition of glutamatergic hyperfunction reduces addictive 
      behaviors in experimental animals. Specifically, NMDAR antagonists such as 
      MK-801, and an inducer of the expression of glutamate transporter subtype-1 
      (GLT-1) (ceftriaxone) are known to inhibit addictive behavior. The purpose of 
      this study was to determine whether the combined action of a low dose of MK-801 
      and a low dose of ceftriaxone provides better inhibition of the acquisition, 
      extinction, and reinstatement of morphine-induced conditioned place preference 
      (CPP) than either compound alone. METHODS: A morphine-paired CPP experiment was 
      used to study the effects of low doses of MK-801, ceftriaxone and a combination 
      of both on reward-related memory (acquisition, extinction, and reinstatement of 
      morphine preference) in rats. RESULTS: A low dose of neither MK-801 (0.05 mg/kg, 
      i.p.) nor ceftriaxone (25 mg/kg, i.p.) alone effectively impaired CPP behaviors. 
      However, when applied in combination, they reduced the acquisition of 
      morphine-induced CPP and completely prevented morphine reinstatement. Their 
      combination also notably impaired the extinction of morphine-induced CPP. 
      CONCLUSION: The combined action of a low dose of an NMDAR antagonist (MK-801) and 
      GLT-1 activation by ceftriaxone effectively changed different phases of CPP 
      behavior.
FAU - Fan, Yaodong
AU  - Fan Y
AD  - Department of Neurosurgery, Third Affiliated Hospital of Kunming Medical 
      University, Kunming, 650118, China.
FAU - Niu, Haichen
AU  - Niu H
FAU - Rizak, Joshua D
AU  - Rizak JD
FAU - Li, Ling
AU  - Li L
FAU - Wang, Guimei
AU  - Wang G
FAU - Xu, Liqi
AU  - Xu L
FAU - Ren, He
AU  - Ren H
FAU - Lei, Hao
AU  - Lei H
FAU - Yu, Hualin
AU  - Yu H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121003
PL  - Singapore
TA  - Neurosci Bull
JT  - Neuroscience bulletin
JID - 101256850
RN  - 6LR8C1B66Q (Dizocilpine Maleate)
RN  - 75J73V1629 (Ceftriaxone)
RN  - 76I7G6D29C (Morphine)
SB  - IM
MH  - Animals
MH  - Ceftriaxone/*administration & dosage
MH  - Conditioning, Psychological/*drug effects/physiology
MH  - Dizocilpine Maleate/*administration & dosage
MH  - Drug Therapy, Combination
MH  - Extinction, Psychological/*drug effects/physiology
MH  - Memory/drug effects/physiology
MH  - Morphine/*antagonists & inhibitors/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Time Factors
PMC - PMC5561921
EDAT- 2012/10/12 06:00
MHDA- 2013/03/27 06:00
PMCR- 2013/10/01
CRDT- 2012/10/12 06:00
PHST- 2012/03/02 00:00 [received]
PHST- 2012/04/23 00:00 [accepted]
PHST- 2012/10/12 06:00 [entrez]
PHST- 2012/10/12 06:00 [pubmed]
PHST- 2013/03/27 06:00 [medline]
PHST- 2013/10/01 00:00 [pmc-release]
AID - 1269 [pii]
AID - 10.1007/s12264-012-1269-8 [doi]
PST - ppublish
SO  - Neurosci Bull. 2012 Oct;28(5):567-76. doi: 10.1007/s12264-012-1269-8. Epub 2012 
      Oct 3.