PMID- 23055503
OWN - NLM
STAT- MEDLINE
DCOM- 20130103
LR  - 20211021
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 32
IP  - 41
DP  - 2012 Oct 10
TI  - BDNF promotes differentiation and maturation of adult-born neurons through 
      GABAergic transmission.
PG  - 14318-30
LID - 10.1523/JNEUROSCI.0709-12.2012 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) has been implicated in regulating adult 
      neurogenesis in the subgranular zone (SGZ) of the dentate gyrus; however, the 
      mechanism underlying this regulation remains unclear. In this study, we found 
      that Bdnf mRNA localized to distal dendrites of dentate gyrus granule cells 
      isolated from wild-type (WT) mice, but not from Bdnf(klox/klox) mice where the 
      long 3' untranslated region (UTR) of Bdnf mRNA is truncated. KCl-induced membrane 
      depolarization stimulated release of dendritic BDNF translated from long 3' UTR 
      Bdnf mRNA in cultured hippocampal neurons, but not from short 3' UTR Bdnf mRNA. 
      Bdnf(klox/klox) mice exhibited reduced expression of glutamic acid decarboxylase 
      65 (a GABA synthase), increased proliferation of progenitor cells, and impaired 
      differentiation and maturation of newborn neurons in the SGZ. These deficits in 
      adult neurogenesis were rescued with administration of phenobarbital, an enhancer 
      of GABA(A) receptor activity. Furthermore, we observed similar neurogenesis 
      deficits in mice where the receptor for BDNF, TrkB, was selectively abolished in 
      parvalbumin (PV)-expressing GABAergic interneurons. Thus, our data suggest that 
      locally synthesized BDNF in dendrites of granule cells promotes differentiation 
      and maturation of progenitor cells in the SGZ by enhancing GABA release, at least 
      in part, from PV-expressing GABAergic interneurons.
FAU - Waterhouse, Emily G
AU  - Waterhouse EG
AD  - Department of Pharmacology and Physiology, Georgetown University Medical Center, 
      Washington, DC 20057, USA.
FAU - An, Juan Ji
AU  - An JJ
FAU - Orefice, Lauren L
AU  - Orefice LL
FAU - Baydyuk, Maryna
AU  - Baydyuk M
FAU - Liao, Guey-Ying
AU  - Liao GY
FAU - Zheng, Kang
AU  - Zheng K
FAU - Lu, Bai
AU  - Lu B
FAU - Xu, Baoji
AU  - Xu B
LA  - eng
GR  - R01 NS050596/NS/NINDS NIH HHS/United States
GR  - R01 NS073930/NS/NINDS NIH HHS/United States
GR  - F30 DK084717/DK/NIDDK NIH HHS/United States
GR  - F31 NS074840/NS/NINDS NIH HHS/United States
GR  - R56 NS050596/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/metabolism/*physiology
MH  - Cell Differentiation/genetics
MH  - Cells, Cultured
MH  - Female
MH  - Hippocampus/cytology/metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Mice, Transgenic
MH  - Neural Stem Cells/*metabolism
MH  - Neurogenesis/*genetics/physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Synaptic Transmission/*genetics/physiology
MH  - Up-Regulation/*genetics
MH  - gamma-Aminobutyric Acid/*biosynthesis/metabolism
PMC - PMC3519245
MID - NIHMS414409
EDAT- 2012/10/12 06:00
MHDA- 2013/01/04 06:00
PMCR- 2013/04/10
CRDT- 2012/10/12 06:00
PHST- 2012/10/12 06:00 [entrez]
PHST- 2012/10/12 06:00 [pubmed]
PHST- 2013/01/04 06:00 [medline]
PHST- 2013/04/10 00:00 [pmc-release]
AID - 32/41/14318 [pii]
AID - 3803646 [pii]
AID - 10.1523/JNEUROSCI.0709-12.2012 [doi]
PST - ppublish
SO  - J Neurosci. 2012 Oct 10;32(41):14318-30. doi: 10.1523/JNEUROSCI.0709-12.2012.