PMID- 23055873
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121012
LR  - 20211021
IS  - 1551-6776 (Print)
IS  - 1551-6776 (Linking)
VI  - 13
IP  - 2
DP  - 2008 Apr
TI  - Drug dosing during continuous renal replacement therapies.
PG  - 99-113
LID - 10.5863/1551-6776-13.2.99 [doi]
AB  - Continuous renal replacement therapies (CRRT) are used to manage fluid overload 
      and/or renal failure. The continuous nature of the fluid and solute removal has 
      less impact on hemodynamic variables in critically ill patients, making CRRT 
      preferred over intermittent hemodialysis for some patients in the intensive care 
      arena. The impact of CRRT on drug removal is variable depending on the CRRT 
      modality, the ultrafiltrate and dialysate flow rates, the filter, and the 
      patient's residual renal function; all of these may change from patient to 
      patient or even in the same patient depending on the clinical status. However, 
      CRRT modalities are generally more efficient than intermittent hemodialysis at 
      drug removal, in some cases approximating or even exceeding normal renal 
      function, resulting in a significant risk of subtherapeutic dosing if 
      conventional hemodialysis dosing recommendations are followed. This annotated 
      bibliography provides a summary of publications analyzing drug removal during 
      CRRT, including CRRT settings and drug clearance values found in each study. 
      Caution is warranted as findings from one study may not be generalizable to all 
      patients due to the many factors that influence drug removal. Serum drug 
      concentrations should be monitored when available, and patient clinical status is 
      exceedingly important for following expected and unexpected responses to drug 
      therapies. Reviews on general drug dosing calculations in CRRT are available 
      elsewhere.
FAU - Thompson, A Jill
AU  - Thompson AJ
AD  - Department of Pharmacy Services and Department of Clinical Pharmacy and Outcomes 
      Sciences, Medical University of South Carolina, Charleston, South Carolina.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Pediatr Pharmacol Ther
JT  - The journal of pediatric pharmacology and therapeutics : JPPT : the official 
      journal of PPAG
JID - 101089851
PMC - PMC3462066
OTO - NOTNLM
OT  - hemodialysis
OT  - hemofiltration
OT  - renal failure
OT  - renal replacement therapies
EDAT- 2008/04/01 00:00
MHDA- 2008/04/01 00:01
PMCR- 2008/04/01
CRDT- 2012/10/12 06:00
PHST- 2012/10/12 06:00 [entrez]
PHST- 2008/04/01 00:00 [pubmed]
PHST- 2008/04/01 00:01 [medline]
PHST- 2008/04/01 00:00 [pmc-release]
AID - 10.5863/1551-6776-13.2.99 [doi]
PST - ppublish
SO  - J Pediatr Pharmacol Ther. 2008 Apr;13(2):99-113. doi: 10.5863/1551-6776-13.2.99.