PMID- 23056073
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121012
LR  - 20211021
IS  - 1896-9151 (Electronic)
IS  - 1734-1922 (Print)
IS  - 1734-1922 (Linking)
VI  - 8
IP  - 4
DP  - 2012 Sep 8
TI  - Evaluation of glutathione S-transferase P1 genetic variants affecting type-2 
      diabetes susceptibility and glycemic control.
PG  - 631-6
LID - 10.5114/aoms.2012.30286 [doi]
AB  - INTRODUCTION: Type 2 diabetes mellitus (T2DM) is associated with increased 
      production of reactive oxygen species and a reduction in antioxidant defenses 
      leading to oxidative stress. Glutathione S-transferases (GSTs) modulate oxidative 
      stress. The present cross-sectional study was aimed at investigating the 
      association between the GSTP1 gene polymorphism and T2DM and to clarify their 
      effect on the glycemic control parameters. MATERIAL AND METHODS: From the 
      Egyptian population, we enrolled 112 T2DM patients and 188 healthy controls 
      matched for age, sex and origin. Serum lipid profile, blood-glucose level, 
      glycated hemoglobin (HbA(1c)) and body mass index (BMI) were measured. DNA was 
      extracted from the blood samples. Polymerase chain reaction-restriction fragment 
      length polymorphism (PCR-RFLP) was used to measure GSTP1 Ile(105)Val gene 
      polymorphism of study participants. RESULTS: The frequency of the Val allele in 
      exon 5 of the GSTP1 gene in patients with T2DM was higher than that observed in 
      healthy controls (15.2% vs. 9.6%); the difference was considered statistically 
      significant when compared to Ile allele carriers (p = 0.03). The presence of the 
      GSTP1 heterozygous mutant allele Ile/Val was more common in subjects with T2DM 
      than in the control group (30.4% and 19.2%, respectively; p = 0.02). Variation in 
      the GSTP1 gene was associated with BMI (p = 0.02) and not associated with 
      glycemic control parameters (fasting serum glucose and HbA(1c)) or 
      smoking-related risk of T2DM. CONCLUSIONS: GSTP1 gene polymorphism may play a 
      significant role in increasing the susceptibility to and risk of T2DM and obesity 
      regardless of smoking status and had no apparent effect on HbA(1c) in patients 
      with diabetes mellitus.
FAU - Amer, Mahmoud A
AU  - Amer MA
AD  - Department of Pharmacology, Faculty of Pharmacy, Sinai University, El-Arish, 
      Egypt.
FAU - Ghattas, Maivel H
AU  - Ghattas MH
FAU - Abo-Elmatty, Dina M
AU  - Abo-Elmatty DM
FAU - Abou-El-Ela, Soad H
AU  - Abou-El-Ela SH
LA  - eng
PT  - Journal Article
PL  - Poland
TA  - Arch Med Sci
JT  - Archives of medical science : AMS
JID - 101258257
PMC - PMC3460499
OTO - NOTNLM
OT  - GSTP1
OT  - body mass index
OT  - glycated hemoglobin
OT  - polymerase chain reaction-restriction fragment length polymorphism
OT  - type 2 diabetes mellitus
EDAT- 2012/10/12 06:00
MHDA- 2012/10/12 06:01
PMCR- 2012/09/08
CRDT- 2012/10/12 06:00
PHST- 2011/09/04 00:00 [received]
PHST- 2011/11/14 00:00 [revised]
PHST- 2011/12/05 00:00 [accepted]
PHST- 2012/10/12 06:00 [entrez]
PHST- 2012/10/12 06:00 [pubmed]
PHST- 2012/10/12 06:01 [medline]
PHST- 2012/09/08 00:00 [pmc-release]
AID - 19268 [pii]
AID - 10.5114/aoms.2012.30286 [doi]
PST - ppublish
SO  - Arch Med Sci. 2012 Sep 8;8(4):631-6. doi: 10.5114/aoms.2012.30286.