PMID- 23057479
OWN - NLM
STAT- MEDLINE
DCOM- 20130524
LR  - 20121204
IS  - 1743-6109 (Electronic)
IS  - 1743-6095 (Linking)
VI  - 9
IP  - 12
DP  - 2012 Dec
TI  - Delay in seeking medical help in patients with new-onset erectile dysfunction 
      remained high over and despite the PDE5 era--an ecological study.
PG  - 3239-46
LID - 10.1111/j.1743-6109.2012.02953.x [doi]
AB  - INTRODUCTION: It is common knowledge among researchers that erectile dysfunction 
      (ED) is an important sentinel marker of cardiovascular and overall men's health. 
      AIM: Determine whether the delay of time between ED onset and seeking medical 
      help (DSH), considered as a proxy of awareness of the importance of ED for 
      overall men's health, has shortened during the phosphodiesterase type 5 
      inhibitors (PDE5) era. METHODS: Complete data from 619 patients seeking first 
      medical help for new-onset ED as their primary disorder between July 2000 and 
      July 2010 were analyzed (i.e., DSH, ED severity as defined by the International 
      Index of Erectile Function-erectile function [IIEF-EF] domain score, patient's 
      awareness of any PDE5, and Charlson Comorbidity Index [CCI]). Analysis of 
      variance tested DSH throughout the 10-year time frame. Cox regression models 
      tested the association between predictors and DSH. MAIN OUTCOME MEASURES: Assess 
      if DSH has shortened throughout PDE5 era. Evaluate potential predictors of DSH. 
      RESULTS: Overall, mean DSH was 30.2 months (median 12.0; range 5-300 months). DSH 
      shortened throughout the analyzed 10-year period (F = 1.918; P = 0.047), with a 
      significant drop only from year 2009 (DSH up to year 2008 vs. from year 2009: 
      31.0 months [12.0] vs. 7.5 months [6.0], respectively; P < 0.001). Age, CCI, 
      educational status, and ED severity did not significantly change over time. As a 
      whole, 560 patients (90.5%) were aware of PDE5 at the time of their first office 
      visit. PDE5 awareness emerged as an univarible and multivariable predictor of a 
      shortened DSH. Conversely, DSH was not clearly associated with age, CCI, 
      educational status, or ED severity. CONCLUSIONS: Delay in seeking medical help in 
      new-onset ED patients remained high over the PDE5 era, with a significant drop 
      only from the year 2009. PDE5 awareness emerged as an independent predictor of 
      shortening of this delay.
CI  - (c) 2012 International Society for Sexual Medicine.
FAU - Salonia, Andrea
AU  - Salonia A
AD  - Department of Urology, University Vita-Salute San Raffaele, Milan, Italy. 
      salonia.andrea@hsr.it
FAU - Ferrari, Matteo
AU  - Ferrari M
FAU - Sacca, Antonino
AU  - Sacca A
FAU - Pellucchi, Federico
AU  - Pellucchi F
FAU - Castagna, Giulia
AU  - Castagna G
FAU - Clementi, Maria Chiara
AU  - Clementi MC
FAU - Matloob, Rayan
AU  - Matloob R
FAU - Briganti, Alberto
AU  - Briganti A
FAU - Rigatti, Patrizio
AU  - Rigatti P
FAU - Montorsi, Francesco
AU  - Montorsi F
LA  - eng
PT  - Journal Article
DEP - 20121011
PL  - Netherlands
TA  - J Sex Med
JT  - The journal of sexual medicine
JID - 101230693
RN  - 0 (Phosphodiesterase 5 Inhibitors)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Analysis of Variance
MH  - Comorbidity
MH  - Educational Status
MH  - Erectile Dysfunction/*drug therapy
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Phosphodiesterase 5 Inhibitors/therapeutic use
MH  - Regression Analysis
MH  - Severity of Illness Index
MH  - *Time-to-Treatment
MH  - Young Adult
EDAT- 2012/10/13 06:00
MHDA- 2013/05/28 06:00
CRDT- 2012/10/13 06:00
PHST- 2012/10/13 06:00 [entrez]
PHST- 2012/10/13 06:00 [pubmed]
PHST- 2013/05/28 06:00 [medline]
AID - S1743-6095(15)33839-X [pii]
AID - 10.1111/j.1743-6109.2012.02953.x [doi]
PST - ppublish
SO  - J Sex Med. 2012 Dec;9(12):3239-46. doi: 10.1111/j.1743-6109.2012.02953.x. Epub 
      2012 Oct 11.