PMID- 23057653
OWN - NLM
STAT- MEDLINE
DCOM- 20130930
LR  - 20220331
IS  - 1365-2265 (Electronic)
IS  - 0300-0664 (Linking)
VI  - 78
IP  - 5
DP  - 2013 May
TI  - Prevalence and long-term follow-up outcomes of testicular adrenal rest tumours in 
      children and adolescent males with congenital adrenal hyperplasia.
PG  - 667-72
LID - 10.1111/cen.12033 [doi]
AB  - OBJECTIVE: There are a few studies regarding the prevalence of testicular adrenal 
      rest tumours (TARTs) in boys and adolescent males with congenital adrenal 
      hyperplasia (CAH), and there is little information regarding the treatment 
      outcomes in patients with TARTs. The aim of this study was to determine the 
      long-term treatment outcomes in boys and adolescent males with CAH. PATIENTS AND 
      METHODS: Sixty boys and adolescent males with CAH, who were between 2 and 
      18 years of age, were included in the study. Fifty-five patients had 
      21-hydroxylase deficiency (21-OHD), and five patients had 11-beta hydroxylase 
      deficiency (11beta-OHD). All patients were screened for TARTs by scrotal 
      ultrasonography (US) performed by an experienced radiologist. RESULTS: TART 
      prevalence was 18.3% in 2-18 years' of age; eight patients had 21-OHD, and three 
      had 11beta-OHD. The youngest patient with TART was 4 years old, whereas eight 
      patients with RTs were at puberty. Only two patients had tight metabolic control: 
      eight patients had stage 2, one had stage 4, and two had stage five rest tumours. 
      In four patients with stage 2 TARTs, tumours disappeared after high-dose steroid 
      treatment and did not recur. Shrinkage of tumour was observed in two patients. 
      Testis-sparing surgery was performed in one patient with stage five tumour. 
      Gonadal functions were normal in patients with partially regressed tumours. Two 
      patients became fathers of healthy male off-springs. CONCLUSIONS: Detection and 
      treatment for TARTs in children with CAH at younger ages, earlier stages, may 
      prevent infertility in adulthood. Therefore, we recommend that scrotal US 
      screening should be performed in every 1-2 years starting from early childhood.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - Aycan, Zehra
AU  - Aycan Z
AD  - Clinics of Pediatric Endocrinology, School of Medicine, Yildirim Beyazit 
      University, Ankara, Turkey.
FAU - Bas, Veysel N
AU  - Bas VN
FAU - Cetinkaya, Semra
AU  - Cetinkaya S
FAU - Yilmaz Agladioglu, Sebahat
AU  - Yilmaz Agladioglu S
FAU - Tiryaki, Tugrul
AU  - Tiryaki T
LA  - eng
PT  - Journal Article
PL  - England
TA  - Clin Endocrinol (Oxf)
JT  - Clinical endocrinology
JID - 0346653
RN  - Congenital adrenal hyperplasia due to 11-Beta-hydroxylase deficiency
RN  - Congenital adrenal hyperplasia due to 21 hydroxylase deficiency
SB  - IM
MH  - Adolescent
MH  - Adrenal Hyperplasia, Congenital/*epidemiology
MH  - Adrenal Rest Tumor/*epidemiology
MH  - Child
MH  - Humans
MH  - Male
EDAT- 2012/10/13 06:00
MHDA- 2013/10/01 06:00
CRDT- 2012/10/13 06:00
PHST- 2012/07/23 00:00 [received]
PHST- 2012/08/13 00:00 [revised]
PHST- 2012/08/15 00:00 [revised]
PHST- 2012/09/03 00:00 [accepted]
PHST- 2012/10/13 06:00 [entrez]
PHST- 2012/10/13 06:00 [pubmed]
PHST- 2013/10/01 06:00 [medline]
AID - 10.1111/cen.12033 [doi]
PST - ppublish
SO  - Clin Endocrinol (Oxf). 2013 May;78(5):667-72. doi: 10.1111/cen.12033.