PMID- 23058261
OWN - NLM
STAT- MEDLINE
DCOM- 20140313
LR  - 20180816
IS  - 1873-7862 (Electronic)
IS  - 0924-977X (Linking)
VI  - 23
IP  - 8
DP  - 2013 Aug
TI  - BDNF Val 66 Met and 5-HTTLPR genotype moderate the impact of early psychosocial 
      adversity on plasma brain-derived neurotrophic factor and depressive symptoms: a 
      prospective study.
PG  - 902-9
LID - S0924-977X(12)00267-2 [pii]
LID - 10.1016/j.euroneuro.2012.09.003 [doi]
AB  - Recent studies have emphasized an important role for neurotrophins, such as 
      brain-derived neurotrophic factor (BDNF), in regulating the plasticity of neural 
      circuits involved in the pathophysiology of stress-related diseases. The aim of 
      the present study was to examine the interplay of the BDNF Val(6)(6)Met and the 
      serotonin transporter promoter (5-HTTLPR) polymorphisms in moderating the impact 
      of early-life adversity on BDNF plasma concentration and depressive symptoms. 
      Participants were taken from an epidemiological cohort study following the 
      long-term outcome of early risk factors from birth into young adulthood. In 259 
      individuals (119 males, 140 females), genotyped for the BDNF Val(6)(6)Met and the 
      5-HTTLPR polymorphisms, plasma BDNF was assessed at the age of 19 years. In 
      addition, participants completed the Beck Depression Inventory (BDI). Early 
      adversity was determined according to a family adversity index assessed at 3 
      months of age. Results indicated that individuals homozygous for both the BDNF 
      Val and the 5-HTTLPR L allele showed significantly reduced BDNF levels following 
      exposure to high adversity. In contrast, BDNF levels appeared to be unaffected by 
      early psychosocial adversity in carriers of the BDNF Met or the 5-HTTLPR S 
      allele. While the former group appeared to be most susceptible to depressive 
      symptoms, the impact of early adversity was less pronounced in the latter group. 
      This is the first preliminary evidence indicating that early-life adverse 
      experiences may have lasting sequelae for plasma BDNF levels in humans, 
      highlighting that the susceptibility to this effect is moderated by BDNF Val(6)(6)Met 
      and 5-HTTLPR genotype.
CI  - Copyright (c) 2013. Published by Elsevier B.V.
FAU - Buchmann, Arlette F
AU  - Buchmann AF
AD  - Department of Child and Adolescent Psychiatry and Psychotherapy, Central 
      Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, 
      Germany.
FAU - Hellweg, Rainer
AU  - Hellweg R
FAU - Rietschel, Marcella
AU  - Rietschel M
FAU - Treutlein, Jens
AU  - Treutlein J
FAU - Witt, Stephanie H
AU  - Witt SH
FAU - Zimmermann, Ulrich S
AU  - Zimmermann US
FAU - Schmidt, Martin H
AU  - Schmidt MH
FAU - Esser, Gunter
AU  - Esser G
FAU - Banaschewski, Tobias
AU  - Banaschewski T
FAU - Laucht, Manfred
AU  - Laucht M
FAU - Deuschle, Michael
AU  - Deuschle M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121009
PL  - Netherlands
TA  - Eur Neuropsychopharmacol
JT  - European neuropsychopharmacology : the journal of the European College of 
      Neuropsychopharmacology
JID - 9111390
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (SLC6A4 protein, human)
RN  - 0 (Serotonin Plasma Membrane Transport Proteins)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Amino Acid Substitution
MH  - Brain-Derived Neurotrophic Factor/blood/*genetics/metabolism
MH  - Child
MH  - Cohort Studies
MH  - Depression/epidemiology/*genetics/metabolism/psychology
MH  - Female
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Germany/epidemiology
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Neuronal Plasticity/genetics
MH  - *Polymorphism, Genetic
MH  - Prospective Studies
MH  - Psychology, Child
MH  - Risk Factors
MH  - Serotonin Plasma Membrane Transport Proteins/*genetics/metabolism
MH  - *Stress, Psychological
MH  - Young Adult
OTO - NOTNLM
OT  - 5-HTTLPR
OT  - BDI
OT  - BDNF
OT  - Beck Depression Inventory
OT  - Depression
OT  - Early psychosocial adversity
OT  - Human
OT  - Longitudinal study
OT  - brain-derived neurotrophic factor
OT  - serotonin transporter gene promoter polymorphism
EDAT- 2012/10/13 06:00
MHDA- 2014/03/14 06:00
CRDT- 2012/10/13 06:00
PHST- 2012/06/05 00:00 [received]
PHST- 2012/08/14 00:00 [revised]
PHST- 2012/09/13 00:00 [accepted]
PHST- 2012/10/13 06:00 [entrez]
PHST- 2012/10/13 06:00 [pubmed]
PHST- 2014/03/14 06:00 [medline]
AID - S0924-977X(12)00267-2 [pii]
AID - 10.1016/j.euroneuro.2012.09.003 [doi]
PST - ppublish
SO  - Eur Neuropsychopharmacol. 2013 Aug;23(8):902-9. doi: 
      10.1016/j.euroneuro.2012.09.003. Epub 2012 Oct 9.