PMID- 23059059
OWN - NLM
STAT- MEDLINE
DCOM- 20130507
LR  - 20131121
IS  - 1873-1708 (Electronic)
IS  - 0890-6238 (Linking)
VI  - 34
IP  - 4
DP  - 2012 Dec
TI  - Disruption of blastocyst implantation by triclosan in mice: impacts of repeated 
      and acute doses and combination with bisphenol-A.
PG  - 607-13
LID - S0890-6238(12)00302-4 [pii]
LID - 10.1016/j.reprotox.2012.09.008 [doi]
AB  - Triclosan is an antimicrobial additive in many personal care and household 
      products, and evidence indicates that it can be estrogenic. As estrogen 
      elevations can disrupt blastocyst implantation, we examined the influence of 
      triclosan on implantation in inseminated mice. Doses of 18 and 27 mg/animal/day 
      (about 523 and 785 mg/kg/day) on gestational days (GD) 1-3 reduced the number of 
      implantation sites on GD 6. Single doses on GD 2 or 3 also reduced implantation 
      sites. Subsequently, we examined triclosan in combination with bisphenol-A (BPA), 
      which also can disrupt implantation. Although doses of 4 mg BPA (122 mg/kg) and 9 
      mg triclosan (262 mg/kg) on GD 1-3 were individually ineffective, in combination 
      they reduced the number of implantation sites and also increased gestation 
      length. All of these effects mimicked stronger effects of 17beta-estradiol. These 
      data are consistent with potential estrogenic properties of triclosan, and show 
      that it can act together with BPA.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Crawford, Brent R
AU  - Crawford BR
AD  - Department of Psychology, Neuroscience & Behaviour, McMaster University, 
      Hamilton, Ontario L8S 4K1, Canada.
FAU - Decatanzaro, Denys
AU  - Decatanzaro D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121008
PL  - United States
TA  - Reprod Toxicol
JT  - Reproductive toxicology (Elmsford, N.Y.)
JID - 8803591
RN  - 0 (Anti-Infective Agents, Local)
RN  - 0 (Benzhydryl Compounds)
RN  - 0 (Estrogens, Non-Steroidal)
RN  - 0 (Phenols)
RN  - 4NM5039Y5X (Triclosan)
RN  - MLT3645I99 (bisphenol A)
SB  - IM
MH  - Animals
MH  - Animals, Outbred Strains
MH  - Anti-Infective Agents, Local/administration & dosage/*toxicity
MH  - Benzhydryl Compounds/administration & dosage/*toxicity
MH  - Drug Synergism
MH  - Embryo Implantation/*drug effects
MH  - Estrogens, Non-Steroidal/administration & dosage/*toxicity
MH  - Female
MH  - Gestational Age
MH  - Maternal-Fetal Exchange
MH  - Mice
MH  - Phenols/administration & dosage/*toxicity
MH  - Pregnancy
MH  - Triclosan/administration & dosage/*toxicity
EDAT- 2012/10/13 06:00
MHDA- 2013/05/08 06:00
CRDT- 2012/10/13 06:00
PHST- 2012/05/31 00:00 [received]
PHST- 2012/08/20 00:00 [revised]
PHST- 2012/09/11 00:00 [accepted]
PHST- 2012/10/13 06:00 [entrez]
PHST- 2012/10/13 06:00 [pubmed]
PHST- 2013/05/08 06:00 [medline]
AID - S0890-6238(12)00302-4 [pii]
AID - 10.1016/j.reprotox.2012.09.008 [doi]
PST - ppublish
SO  - Reprod Toxicol. 2012 Dec;34(4):607-13. doi: 10.1016/j.reprotox.2012.09.008. Epub 
      2012 Oct 8.