PMID- 23059769
OWN - NLM
STAT- MEDLINE
DCOM- 20130812
LR  - 20190819
IS  - 1347-4820 (Electronic)
IS  - 1346-9843 (Linking)
VI  - 77
IP  - 2
DP  - 2013
TI  - Cardiopulmonary variables during exercise predict pregnancy outcome in women with 
      congenital heart disease.
PG  - 470-6
AB  - BACKGROUND: Maternal New York Heart Association (NYHA) class is associated with 
      pregnancy outcome in women with congenital heart disease (WCHD), but objective 
      predictive criteria of exercise capacity have not been established. METHODS AND 
      RESULTS: A total of 33 WCHD (age, 28 +/- 5 years; NYHA class, 1.3 +/- 0.6) who had 
      undergone cardiopulmonary exercise testing (CPX) 1.8 +/- 2.2 years before their 
      delivery were retrospectively identified. Maternal, cardiac, and neonatal events 
      occurred in 8 (24%), 12 (36%), and 14 (42%), respectively. All CPX parameters 
      correlated with neonatal birth weight (P<0.05-0.001). Exercise time, peak heart 
      rate (HR), peak systolic blood pressure, and peak oxygen uptake (VO(2)) were 
      associated with cardiac events (P<0.05-0.01), and exercise time and peak VO(2) 
      were also associated with neonatal events (P<0.05). Exercise time, peak HR, and 
      peak VO(2) were associated with at least 1 of the 3 events (P<0.05-0.01). 
      Receiver operating characteristic analysis showed that peak HR <150 beats/min 
      and/or peak VO(2) <22.0 ml . kg(-1) . min(-1), peak VO(2) <26.2 ml . kg(-1) . 
      min(-1), and peak HR <150 beats/min and/or peak VO(2) <25.3 ml . kg(-1) . min(-1) 
      predicted a high probability of maternal cardiac, neonatal, and maternal cardiac 
      and/or neonatal event, respectively. CONCLUSIONS: CPX parameters predict 
      pregnancy outcome and peak HR >/= 150 beats/min and/or peak VO(2) >/= 25 ml . kg(-1) 
      . min(-1) may be reference value(s) for a safer pregnancy outcome in WCHD.
FAU - Ohuchi, Hideo
AU  - Ohuchi H
AD  - Department of Pediatric Cardiology, National Cerebral and Cardiovascular Center, 
      5-7-1 Fujishiro-dai, Suita 565-8565, Japan. hohuchi@hsp.ncvc.go.jp
FAU - Tanabe, Yuka
AU  - Tanabe Y
FAU - Kamiya, Chizuko
AU  - Kamiya C
FAU - Noritake, Kanae
AU  - Noritake K
FAU - Yasuda, Kenji
AU  - Yasuda K
FAU - Miyazaki, Aya
AU  - Miyazaki A
FAU - Ikeda, Tomoaki
AU  - Ikeda T
FAU - Yamada, Osamu
AU  - Yamada O
LA  - eng
PT  - Journal Article
DEP - 20121012
PL  - Japan
TA  - Circ J
JT  - Circulation journal : official journal of the Japanese Circulation Society
JID - 101137683
SB  - IM
MH  - Adult
MH  - Arrhythmias, Cardiac/diagnosis/physiopathology
MH  - Birth Weight/physiology
MH  - Blood Pressure/physiology
MH  - Exercise/*physiology
MH  - Exercise Test
MH  - Exercise Tolerance/physiology
MH  - Female
MH  - Heart Defects, Congenital/*diagnosis/epidemiology/*physiopathology
MH  - Heart Rate/physiology
MH  - Humans
MH  - Infant, Newborn
MH  - Oxygen Consumption/physiology
MH  - Predictive Value of Tests
MH  - Pregnancy
MH  - Pregnancy Complications, Cardiovascular/*diagnosis/epidemiology/*physiopathology
MH  - Pregnancy Outcome/epidemiology
MH  - Prevalence
MH  - Prognosis
MH  - Retrospective Studies
MH  - Young Adult
EDAT- 2012/10/13 06:00
MHDA- 2013/08/13 06:00
CRDT- 2012/10/13 06:00
PHST- 2012/10/13 06:00 [entrez]
PHST- 2012/10/13 06:00 [pubmed]
PHST- 2013/08/13 06:00 [medline]
AID - DN/JST.JSTAGE/circj/CJ-12-0485 [pii]
AID - 10.1253/circj.cj-12-0485 [doi]
PST - ppublish
SO  - Circ J. 2013;77(2):470-6. doi: 10.1253/circj.cj-12-0485. Epub 2012 Oct 12.