PMID- 23059884
OWN - NLM
STAT- MEDLINE
DCOM- 20130321
LR  - 20161221
IS  - 1699-5848 (Electronic)
IS  - 0213-3911 (Linking)
VI  - 27
IP  - 12
DP  - 2012 Dec
TI  - Fluorescence in situ hybridization for ambiguous melanocytic tumors.
PG  - 1539-42
LID - 10.14670/HH-27.1539 [doi]
AB  - The large majority of melanocytic lesions can be reliably classified as either 
      benign or malignant based upon morphology alone, but a minority of lesions 
      remains difficult to classify by traditional histologic methods. Recently, a 
      panel of fluorescence in situ hybridization (FISH) probes targeting loci on 
      chromosomes 6 and 11 has emerged as a powerful tool to discriminate melanoma from 
      nevi. This has been validated in numerous difficult diagnostic scenarios. In 
      addition, this same FISH panel has been shown to provide independent prognostic 
      information in traditional melanomas. There is accumulating evidence that FISH 
      targeting these loci as well as several other key chromosomal loci such as 9p21 
      and 8q24 can provide valuable prognostic information in histologically ambiguous 
      melanocytic tumors. However, since the vast majority of atypical spitz tumors 
      have an indolent course, larger studies including adequate numbers of cases with 
      adverse events is necessary to provide sufficient proof of its role in clinically 
      relevant cases. In this review, we discuss the current literature and studies to 
      date on this topic.
FAU - Gammon, B
AU  - Gammon B
AD  - Northwestern University, Department of Dermatology, Chicago, IL 60611, USA. 
      bryan.gammon@gmail.com
FAU - Gerami, P
AU  - Gerami P
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Spain
TA  - Histol Histopathol
JT  - Histology and histopathology
JID - 8609357
SB  - IM
MH  - Chromosome Aberrations
MH  - Diagnosis, Differential
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - Lymphatic Metastasis/diagnosis/genetics
MH  - Melanoma/*diagnosis/*genetics/secondary
MH  - Nevus/*diagnosis/*genetics
MH  - Nevus, Epithelioid and Spindle Cell/diagnosis/genetics
MH  - Sentinel Lymph Node Biopsy
MH  - Skin Neoplasms/*diagnosis/*genetics
EDAT- 2012/10/13 06:00
MHDA- 2013/03/22 06:00
CRDT- 2012/10/13 06:00
PHST- 2012/10/13 06:00 [entrez]
PHST- 2012/10/13 06:00 [pubmed]
PHST- 2013/03/22 06:00 [medline]
AID - 10.14670/HH-27.1539 [doi]
PST - ppublish
SO  - Histol Histopathol. 2012 Dec;27(12):1539-42. doi: 10.14670/HH-27.1539.