PMID- 23060009
OWN - NLM
STAT- MEDLINE
DCOM- 20130312
LR  - 20161125
IS  - 1468-2060 (Electronic)
IS  - 0003-4967 (Linking)
VI  - 72
IP  - 2
DP  - 2013 Feb
TI  - In patients with early rheumatoid arthritis, the new ACR/EULAR definition of 
      remission identifies patients with persistent absence of functional disability 
      and suppression of ultrasonographic synovitis.
PG  - 245-9
LID - 10.1136/annrheumdis-2012-201817 [doi]
AB  - OBJECTIVES: To test the American College of Rheumatology/European League Against 
      Rheumatism (ACR/EULAR) and disease activity score in 44 and 28 joints (DAS, 
      DAS28) definitions of remission in early rheumatoid arthritis (RA), against 
      disability and ultrasound-detectable synovitis. METHODS: In an observational 
      study of early RA patients, remission rates were determined and compared in 166 
      patients. The remission definitions included the simplified disease activity 
      index (SDAI</=3.3), ACR/EULAR (categorical), DAS28 (<2.6) and DAS (<1.6). The 
      health assessment questionnaire (HAQ) was completed at baseline and 12 months, 
      power Doppler-positive synovitis (PDPS) was assessed at baseline, 6 and 12 
      months. Cross-sectionally, the outcomes were low functional disability (HAQ</=0.5) 
      or absent PDPS in all joints, while longitudinally the outcomes were stable low 
      functional disability and persistent absent PDPS in all joints. RESULTS: At 
      baseline, 33.7% of patients achieved DAS28 remission, 43.37% DAS remission, 16.8% 
      SDAI remission, 13.8% ACR/EULAR remission. DAS28, SDAI and ACR/EULAR remission 
      was cross-sectionally associated with low functional disability and absent PDPS. 
      All definitions were longitudinally associated with low functional disability: 
      positive likelihood ratios (LR+) of 3.24 for DAS28, 2.14 for DAS, 4.86 for SDAI, 
      5.67 for ACR/EULAR criteria, and with absent PDPS for DAS28 (LR+ 1.66), SDAI (LR+ 
      6.46), ACR/EULAR (LR+ 5.07). CONCLUSIONS: The new remission definitions confirmed 
      their validity in an observational setting and identify patients with better 
      disease control.
FAU - Sakellariou, Garifallia
AU  - Sakellariou G
AD  - IRCCS Fondazione Policlinico San Matteo, Piazzale Golgi, Pavia 27100, Italy.
FAU - Scire, Carlo Alberto
AU  - Scire CA
FAU - Verstappen, Suzanne M M
AU  - Verstappen SM
FAU - Montecucco, Carlomaurizio
AU  - Montecucco C
FAU - Caporali, Roberto
AU  - Caporali R
LA  - eng
PT  - Journal Article
DEP - 20121011
PL  - England
TA  - Ann Rheum Dis
JT  - Annals of the rheumatic diseases
JID - 0372355
RN  - 0 (Antirheumatic Agents)
SB  - IM
MH  - Aged
MH  - Antirheumatic Agents/therapeutic use
MH  - Arthritis, Rheumatoid/*classification/*diagnostic imaging/drug therapy
MH  - Cross-Sectional Studies
MH  - Female
MH  - Health Status
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Remission, Spontaneous
MH  - Severity of Illness Index
MH  - Synovitis/*diagnostic imaging/etiology
MH  - Ultrasonography
EDAT- 2012/10/13 06:00
MHDA- 2013/03/13 06:00
CRDT- 2012/10/13 06:00
PHST- 2012/10/13 06:00 [entrez]
PHST- 2012/10/13 06:00 [pubmed]
PHST- 2013/03/13 06:00 [medline]
AID - annrheumdis-2012-201817 [pii]
AID - 10.1136/annrheumdis-2012-201817 [doi]
PST - ppublish
SO  - Ann Rheum Dis. 2013 Feb;72(2):245-9. doi: 10.1136/annrheumdis-2012-201817. Epub 
      2012 Oct 11.