PMID- 23060455
OWN - NLM
STAT- MEDLINE
DCOM- 20140214
LR  - 20161125
IS  - 2047-2412 (Electronic)
IS  - 2047-2404 (Linking)
VI  - 14
IP  - 6
DP  - 2013 Jun
TI  - Tissue Doppler imaging and prognosis in asymptomatic or mildly symptomatic 
      patients with hypertrophic cardiomyopathy.
PG  - 544-9
LID - 10.1093/ehjci/jes200 [doi]
AB  - AIMS: Assessment of left ventricular (LV) systolic and diastolic functions by 
      tissue Doppler imaging (TDI) has been reported to be useful for predicting the 
      prognosis in patients with hypertrophic cardiomyopathy (HCM). The purpose of this 
      study was to evaluate the clinical significance of TDI parameters for the 
      prediction of cardiovascular events in asymptomatic or mildly symptomatic 
      patients with HCM. METHODS AND RESULTS: Eighty-five HCM patients (52 males, 55.6 
      +/- 14.8 years.) belonging to the New York Heart Association (NYHA) functional 
      class I or II were enrolled in this study. Patients with the LV systolic 
      dysfunction or a clinically documented history of atrial fibrillation were 
      excluded. The combined endpoints were HCM-related death; admission for heart 
      failure or stroke; new episode of atrial fibrillation; and worsening of heart 
      failure symptoms (NYHA class III). During a follow-up period of 4.5 +/- 1.7 years, 
      11 patients achieved the combined endpoints. Patients who experienced 
      cardiovascular events had a larger LV size and left atrial volume compared with 
      those who did not. Peak systolic, early diastolic (e'), and late diastolic TDI 
      velocities at the septal corner were lower in patients who experienced 
      cardiovascular events; moreover, the septal E/e' value was higher in these 
      patients. Multivariate forward regression analysis revealed the deceleration 
      times of E and the septal E/e' to be independent predictors of cardiovascular 
      events. CONCLUSION: Assessment of the diastolic function by TDI is useful for 
      risk stratification in HCM patients with no or mild symptoms. TDI measurements 
      should be incorporated into the clinical management of HCM.
FAU - Kitaoka, Hiroaki
AU  - Kitaoka H
AD  - Division of Cardiology, Department of Medicine and Geriatrics, Kochi Medical 
      School, Oko-cho, Nankoku-shi, Kochi 783-8505, Japan. kitaokah@kochi-u.ac.jp
FAU - Kubo, Toru
AU  - Kubo T
FAU - Hayashi, Kayo
AU  - Hayashi K
FAU - Yamasaki, Naohito
AU  - Yamasaki N
FAU - Matsumura, Yoshihisa
AU  - Matsumura Y
FAU - Furuno, Takashi
AU  - Furuno T
FAU - Doi, Yoshinori L
AU  - Doi YL
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20121011
PL  - England
TA  - Eur Heart J Cardiovasc Imaging
JT  - European heart journal. Cardiovascular Imaging
JID - 101573788
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Cardiomyopathy, Hypertrophic/*diagnostic imaging/*mortality/physiopathology
MH  - Cohort Studies
MH  - Echocardiography, Doppler/*methods
MH  - Elasticity Imaging Techniques/*methods
MH  - Female
MH  - Heart Failure, Systolic/diagnostic imaging/mortality/physiopathology
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Risk Assessment
MH  - Severity of Illness Index
MH  - Sex Factors
MH  - Statistics, Nonparametric
MH  - Stroke Volume/*physiology
MH  - Survival Rate
MH  - Ventricular Dysfunction, Left/*diagnostic imaging/mortality/physiopathology
OTO - NOTNLM
OT  - Hypertrophic cardiomyopathy
OT  - Prognosis
OT  - Symptom
OT  - Tissue doppler imaging
EDAT- 2012/10/13 06:00
MHDA- 2014/02/15 06:00
CRDT- 2012/10/13 06:00
PHST- 2012/10/13 06:00 [entrez]
PHST- 2012/10/13 06:00 [pubmed]
PHST- 2014/02/15 06:00 [medline]
AID - jes200 [pii]
AID - 10.1093/ehjci/jes200 [doi]
PST - ppublish
SO  - Eur Heart J Cardiovasc Imaging. 2013 Jun;14(6):544-9. doi: 10.1093/ehjci/jes200. 
      Epub 2012 Oct 11.