PMID- 23060889
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121015
LR  - 20211021
IS  - 1664-462X (Electronic)
IS  - 1664-462X (Linking)
VI  - 3
DP  - 2012
TI  - Global SUMO Proteome Responses Guide Gene Regulation, mRNA Biogenesis, and Plant 
      Stress Responses.
PG  - 215
LID - 10.3389/fpls.2012.00215 [doi]
LID - 215
AB  - Small Ubiquitin-like MOdifier (SUMO) is a key regulator of abiotic stress, 
      disease resistance, and development in plants. The identification of >350 plant 
      SUMO targets has revealed many processes modulated by SUMO and potential 
      consequences of SUMO on its targets. Importantly, highly related proteins are 
      SUMO-modified in plants, yeast, and metazoans. Overlapping SUMO targets include 
      heat-shock proteins (HSPs), transcription regulators, histones, histone-modifying 
      enzymes, proteins involved in DNA damage repair, but also proteins involved in 
      mRNA biogenesis and nucleo-cytoplasmic transport. Proteomics studies indicate key 
      roles for SUMO in gene repression by controlling histone (de)acetylation activity 
      at genomic loci. The responsible heavily sumoylated transcriptional repressor 
      complexes are recruited by plant transcription factors (TFs) containing an 
      (ERF)-associated Amphiphilic Repression (EAR) motif. These TFs are not 
      necessarily themselves a SUMO target. Conversely, SUMO acetylation (Ac) prevents 
      binding of downstream partners by blocking binding of their SUMO-interaction 
      peptide motifs to Ac-SUMO. In addition, SUMO acetylation has emerged as a 
      mechanism to recruit specifically bromodomains. Bromodomains are generally linked 
      with gene activation. These findings strengthen the idea of a bi-directional 
      sumo-acetylation switch in gene regulation. Quantitative proteomics has 
      highlighted that global sumoylation provides a dynamic response to protein damage 
      involving SUMO chain-mediated protein degradation, but also SUMO E3 
      ligase-dependent transcription of HSP genes. With these insights in SUMO function 
      and novel technical advancements, we can now study SUMO dynamics in responses to 
      (a)biotic stress in plants.
FAU - Mazur, Magdalena J
AU  - Mazur MJ
AD  - Molecular Plant Pathology, Swammerdam Institute for Life Sciences, University of 
      Amsterdam Amsterdam, Netherlands.
FAU - van den Burg, Harrold A
AU  - van den Burg HA
LA  - eng
PT  - Journal Article
DEP - 20120917
PL  - Switzerland
TA  - Front Plant Sci
JT  - Frontiers in plant science
JID - 101568200
PMC - PMC3443746
OTO - NOTNLM
OT  - SUMO
OT  - acetylation
OT  - chromatin
OT  - heat shock
OT  - histones
OT  - stress
EDAT- 2012/10/13 06:00
MHDA- 2012/10/13 06:01
PMCR- 2012/01/01
CRDT- 2012/10/13 06:00
PHST- 2012/07/02 00:00 [received]
PHST- 2012/08/23 00:00 [accepted]
PHST- 2012/10/13 06:00 [entrez]
PHST- 2012/10/13 06:00 [pubmed]
PHST- 2012/10/13 06:01 [medline]
PHST- 2012/01/01 00:00 [pmc-release]
AID - 10.3389/fpls.2012.00215 [doi]
PST - epublish
SO  - Front Plant Sci. 2012 Sep 17;3:215. doi: 10.3389/fpls.2012.00215. eCollection 
      2012.