PMID- 23062542
OWN - NLM
STAT- MEDLINE
DCOM- 20130109
LR  - 20121102
IS  - 1558-3597 (Electronic)
IS  - 0735-1097 (Linking)
VI  - 60
IP  - 19
DP  - 2012 Nov 6
TI  - Cardiac resynchronization and quality of life in patients with minimally 
      symptomatic heart failure.
PG  - 1940-4
LID - S0735-1097(12)04115-0 [pii]
LID - 10.1016/j.jacc.2012.06.054 [doi]
AB  - OBJECTIVES: This study compared the quality of life (QOL) of patients with 
      cardiac resynchronization therapy (CRT) and an implantable 
      cardioverter-defibrillator (ICD) to patients with an ICD only. BACKGROUND: CRT 
      with ICD is associated with a reduction in heart failure risk among minimally 
      symptomatic patients. It is unknown whether this improves QOL. METHODS: This 
      study uses the MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial 
      With Cardiac Resynchronization Therapy) data. The MADIT-CRT enrolled 1,820 
      patients at 110 centers across 14 countries. Patients had ischemic cardiomyopathy 
      (New York Heart Association [NYHA] functional class I or II) or nonischemic 
      cardiomyopathy (NYHA functional class II only), sinus rhythm, an ejection 
      fraction of 30% or less, and prolonged intraventricular conduction with a QRS 
      duration of 130 ms or more. QOL was evaluated on the 1,699 patients with baseline 
      and follow-up measures using the Kansas City Cardiomyopathy Questionnaire (KCCQ). 
      Six dimensions (Physical Limitation, Symptom Stability, Symptom Frequency, 
      Symptom Burden, Quality of Life, and Social Limitations) and 3 summary scores 
      (Total Symptom, Clinical Summary, and Overall Summary) were analyzed. RESULTS: 
      During an average follow-up of 2.4 years, the CRT-ICD group had greater 
      improvement than the ICD-only group on all KCCQ measures (p < 0.05 on each 
      scale). These differences were significant among patients with left bundle branch 
      block conduction disturbance (n = 1,204, p < 0.01 on each scale), but not among 
      patients without left bundle branch block (n = 494). CONCLUSIONS: Compared with 
      patients with ICD only, CRT-ICD is associated with greater improvement in QOL 
      among relatively asymptomatic patients, specifically among those with left bundle 
      branch conduction disturbance.
CI  - Copyright (c) 2012 American College of Cardiology Foundation. Published by Elsevier 
      Inc. All rights reserved.
FAU - Veazie, Peter J
AU  - Veazie PJ
AD  - Department of Community and Preventive Medicine, University of Rochester Medical 
      Center, Rochester, NY, USA. peter_veazie@urmc.rochester.edu
FAU - Noyes, Katia
AU  - Noyes K
FAU - Li, Qinghua
AU  - Li Q
FAU - Hall, W Jackson
AU  - Hall WJ
FAU - Buttaccio, April
AU  - Buttaccio A
FAU - Thevenet-Morrison, Kelly
AU  - Thevenet-Morrison K
FAU - Moss, Arthur J
AU  - Moss AJ
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
DEP - 20121010
PL  - United States
TA  - J Am Coll Cardiol
JT  - Journal of the American College of Cardiology
JID - 8301365
SB  - IM
MH  - Aged
MH  - Cardiac Resynchronization Therapy/methods/*psychology
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure/diagnosis/*psychology/*therapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Quality of Life/*psychology
MH  - Symptom Assessment/methods
MH  - Treatment Outcome
EDAT- 2012/10/16 06:00
MHDA- 2013/01/10 06:00
CRDT- 2012/10/16 06:00
PHST- 2012/03/30 00:00 [received]
PHST- 2012/06/15 00:00 [revised]
PHST- 2012/06/19 00:00 [accepted]
PHST- 2012/10/16 06:00 [entrez]
PHST- 2012/10/16 06:00 [pubmed]
PHST- 2013/01/10 06:00 [medline]
AID - S0735-1097(12)04115-0 [pii]
AID - 10.1016/j.jacc.2012.06.054 [doi]
PST - ppublish
SO  - J Am Coll Cardiol. 2012 Nov 6;60(19):1940-4. doi: 10.1016/j.jacc.2012.06.054. 
      Epub 2012 Oct 10.