PMID- 23062672
OWN - NLM
STAT- MEDLINE
DCOM- 20140421
LR  - 20130506
IS  - 1873-3360 (Electronic)
IS  - 0306-4530 (Linking)
VI  - 38
IP  - 6
DP  - 2013 Jun
TI  - Altered chemokine levels in the cerebrospinal fluid and plasma of suicide 
      attempters.
PG  - 853-62
LID - S0306-4530(12)00326-5 [pii]
LID - 10.1016/j.psyneuen.2012.09.010 [doi]
AB  - Chemokines constitute a class of small inflammatory proteins that control the 
      chemotaxis of leukocytes. They are also present in the central nervous system 
      (CNS) and contribute to diverse physiological functions, such as the regulation 
      of cell migration, axonal growth and neuronal survival. It is to date not known 
      whether chemokines in the CNS are affected in psychiatric disorders. In this 
      study, chemokine levels were measured in the cerebrospinal fluid (CSF) of 137 
      psychiatric patients in conjunction to a suicide attempt, and 43 healthy 
      controls. A subgroup of patients (n = 42) was followed up with blood samples 12 
      years after the initial CSF collection, when they did not show suicidal behavior. 
      The follow-up chemokine levels were compared to those of psychiatric patients (n 
      = 17) who had never attempted suicide. Ultra-sensitive chemokine multiplex 
      immunoassay was used to quantify eotaxin-1 (CCL11), interferon gamma-induced 
      protein-10 (IP-10, CXCL10), macrophage inflammatory protein-1beta (MIP-1beta, CCL4), 
      monocyte chemotactic protein-1 (MCP-1, CCL2), MCP-4 (CCL13) and thymus and 
      activation regulated chemokine (TARC, CCL17). Patients were diagnosed using 
      DSM-III-R/DSM-IV, and assessed using the Comprehensive Psychopathological Rating 
      Scale (CPRS), including subscales, and the Suicidal Intent Scale (SIS). CSF 
      eotaxin-1, MIP-1beta, MCP-1, MCP-4 and TARC were significantly lower in suicide 
      attempters than in healthy controls. Low chemokine levels were specifically 
      associated with psychotic symptoms and pain. In the samples collected at 
      follow-up, TARC was significantly lower in suicide attempters compared to 
      psychiatric patients who had never attempted suicide. We also found a positive 
      correlation between blood TARC and brain-derived neurotrophic factor (BDNF) 
      levels. Our study thus provides evidence of reduced chemokine levels in suicide 
      attempters, both in the acute suicidal setting, and at long-term, compared to 
      non-attempters. These results warrant future studies on the detailed 
      neurobiological functions of chemokines in psychiatric patients.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Janelidze, Shorena
AU  - Janelidze S
AD  - Psychoimmunology Unit, Section for Psychiatry, Department of Clinical Sciences, 
      Lund University, Lund, Sweden. Shorena.Janelidze@med.lu.se
FAU - Ventorp, Filip
AU  - Ventorp F
FAU - Erhardt, Sophie
AU  - Erhardt S
FAU - Hansson, Oskar
AU  - Hansson O
FAU - Minthon, Lennart
AU  - Minthon L
FAU - Flax, John
AU  - Flax J
FAU - Samuelsson, Martin
AU  - Samuelsson M
FAU - Traskman-Bendz, Lil
AU  - Traskman-Bendz L
FAU - Brundin, Lena
AU  - Brundin L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121009
PL  - England
TA  - Psychoneuroendocrinology
JT  - Psychoneuroendocrinology
JID - 7612148
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Chemokines)
SB  - IM
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/blood/cerebrospinal fluid
MH  - Case-Control Studies
MH  - Chemokines/*blood/*cerebrospinal fluid
MH  - Cross-Sectional Studies
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Mental Disorders/*blood/*cerebrospinal fluid/diagnosis
MH  - Middle Aged
MH  - Pain/blood/cerebrospinal fluid
MH  - *Suicide, Attempted
EDAT- 2012/10/16 06:00
MHDA- 2014/04/22 06:00
CRDT- 2012/10/16 06:00
PHST- 2012/03/30 00:00 [received]
PHST- 2012/09/14 00:00 [revised]
PHST- 2012/09/14 00:00 [accepted]
PHST- 2012/10/16 06:00 [entrez]
PHST- 2012/10/16 06:00 [pubmed]
PHST- 2014/04/22 06:00 [medline]
AID - S0306-4530(12)00326-5 [pii]
AID - 10.1016/j.psyneuen.2012.09.010 [doi]
PST - ppublish
SO  - Psychoneuroendocrinology. 2013 Jun;38(6):853-62. doi: 
      10.1016/j.psyneuen.2012.09.010. Epub 2012 Oct 9.