PMID- 23063133 OWN - NLM STAT- MEDLINE DCOM- 20140123 LR - 20221207 IS - 1873-7862 (Electronic) IS - 0924-977X (Linking) VI - 23 IP - 7 DP - 2013 Jul TI - Genetics of emergent suicidality during antidepressive treatment--data from a naturalistic study on a large sample of inpatients with a major depressive episode. PG - 663-74 LID - S0924-977X(12)00227-1 [pii] LID - 10.1016/j.euroneuro.2012.08.009 [doi] AB - Factors contributing to treatment-emergent suicidal ideation (TESI) using antidepressants have been in the focus of recent research strategies. We investigated previously established clinical predictors of TESI and combined these with several polymorphisms of candidate genes in patients with major depressive disorder. Common polymorphisms involved in the tryptophan hydroxylase 1 (TPH1) and 2 (TPH2), serotonin transporter, monoamine oxidase A (MAOA) and brain-derived neurotrophic factor (BDNF) were investigated in a naturalistic inpatient study of the German research network on depression. We compared patients showing TESI with non-TESI suicidal patients and with non-suicidal patients using univariate tests to detect relevant factors, which were further tested in logistic regression and CART (Classification and Regression Trees) analyses. Of the 269 patients, TESI occurred in 22 patients (17 female), 117 patients were defined as non-TESI suicidal patients, and 130 patients were classified as non-suicidal. When comparing cases with both control groups we found the TPH2 rs1386494 (C/T) polymorphism to be moderately associated with TESI (Univariate tests: TESI vs. non-suicidality: p=0.005; adjusted: p=0.09; TESI vs. non-TESI suicidal patients: p=0.0024; adjusted: p=0.086). This polymorphism remained the only significant genetic factor in addition to clinical predictors in logistic regression and CART analyses. CART analyses suggested interactions with several clinical predictors. Haplotype analyses further supported a contribution of this polymorphism in TESI. The TPH2 rs1386494 (C/T) polymorphism might contribute to the genetic background of TESI. This polymorphism has been previously associated with committed suicide and major depressive disorder. The small number of cases warrants replication in larger patient samples. Lack of a placebo control group hampers definite conclusions on an association with antidepressive treatment. CI - Copyright (c) 2012 Elsevier B.V. and ECNP. All rights reserved. FAU - Musil, Richard AU - Musil R AD - Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Nussbaumstrasse 7, 80336 Munich, Germany. Richard.musil@med.uni-muenchen.de FAU - Zill, Peter AU - Zill P FAU - Seemuller, Florian AU - Seemuller F FAU - Bondy, Brigitta AU - Bondy B FAU - Meyer, Sebastian AU - Meyer S FAU - Spellmann, Ilja AU - Spellmann I FAU - Bender, Wolfram AU - Bender W FAU - Adli, Mazda AU - Adli M FAU - Heuser, Isabella AU - Heuser I FAU - Fisher, Robert AU - Fisher R FAU - Gaebel, Wolfgang AU - Gaebel W FAU - Maier, Wolfgang AU - Maier W FAU - Rietschel, Marcella AU - Rietschel M FAU - Rujescu, Dan AU - Rujescu D FAU - Schennach, Rebecca AU - Schennach R FAU - Moller, Hans-Jurgen AU - Moller HJ FAU - Riedel, Michael AU - Riedel M LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20121011 PL - Netherlands TA - Eur Neuropsychopharmacol JT - European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology JID - 9111390 RN - 0 (Antidepressive Agents) RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Serotonin Plasma Membrane Transport Proteins) RN - EC 1.14.16.4 (TPH1 protein, human) RN - EC 1.14.16.4 (TPH2 protein, human) RN - EC 1.14.16.4 (Tryptophan Hydroxylase) RN - EC 1.4.3.4 (Monoamine Oxidase) RN - EC 1.4.3.4. (monoamine oxidase A, human) SB - IM MH - Adolescent MH - Adult MH - Aged MH - Antidepressive Agents/adverse effects/therapeutic use MH - Brain-Derived Neurotrophic Factor/genetics MH - Case-Control Studies MH - Depressive Disorder, Major/drug therapy/*genetics/*psychology MH - Female MH - Genetic Association Studies MH - Genotype MH - Haplotypes MH - Humans MH - Male MH - Middle Aged MH - *Models, Statistical MH - Monoamine Oxidase/genetics MH - Polymorphism, Genetic MH - Risk Factors MH - Serotonin Plasma Membrane Transport Proteins/genetics MH - *Suicidal Ideation MH - Suicide, Attempted/*statistics & numerical data MH - Tryptophan Hydroxylase/*genetics MH - White People/genetics EDAT- 2012/10/16 06:00 MHDA- 2014/01/24 06:00 CRDT- 2012/10/16 06:00 PHST- 2011/11/30 00:00 [received] PHST- 2012/08/05 00:00 [revised] PHST- 2012/08/06 00:00 [accepted] PHST- 2012/10/16 06:00 [entrez] PHST- 2012/10/16 06:00 [pubmed] PHST- 2014/01/24 06:00 [medline] AID - S0924-977X(12)00227-1 [pii] AID - 10.1016/j.euroneuro.2012.08.009 [doi] PST - ppublish SO - Eur Neuropsychopharmacol. 2013 Jul;23(7):663-74. doi: 10.1016/j.euroneuro.2012.08.009. Epub 2012 Oct 11.