PMID- 23064069
OWN - NLM
STAT- MEDLINE
DCOM- 20121108
LR  - 20151119
IS  - 0385-0684 (Print)
IS  - 0385-0684 (Linking)
VI  - 39
IP  - 10
DP  - 2012 Oct
TI  - [Complete response by rituximab monotherapy in a patient with leukemic mantle 
      cell lymphoma diagnosed by fluorescence in situ hybridization analysis].
PG  - 1547-50
AB  - An 85-year-old male was admitted to a hospital with abdominal discomfort in 
      October, 2010. Severe splenomegaly and mild para-aortic lymphoadenopathy were 
      detected. In addition, an increase in atypical lymphocytes was noticed by bone 
      marrow analyses with weak positive staining of cyclin D1. Subsequently, the 
      fluorescence in situ hybridization(FISH)method confirmed cyclin D1 
      reconstruction, and the fusion signals of the BCL1 and IgH genes were detected, 
      thus providing a definitive diagnosis of leukemic mantle cell lymphoma. After 
      treatment with rituximab monotherapy, the Ki-67 index was stabilized to within 
      10%, and complete response was obtained.
FAU - Okagawa, Yutaka
AU  - Okagawa Y
AD  - Dept. of Gastroenterology and Hematology, Steel Memorial Muroran Hospital, Japan.
FAU - Kuroda, Hiroyuki
AU  - Kuroda H
FAU - Ishikawa, Kazuma
AU  - Ishikawa K
FAU - Yamada, Michiko
AU  - Yamada M
FAU - Hoki, Toshifumi
AU  - Hoki T
FAU - Abe, Tomoyuki
AU  - Abe T
FAU - Sakurai, Tamaki
AU  - Sakurai T
FAU - Fujii, Shigeyuki
AU  - Fujii S
FAU - Maeda, Masahiro
AU  - Maeda M
FAU - Fujita, Miri
AU  - Fujita M
FAU - Jyomen, Wataru
AU  - Jyomen W
FAU - Iyama, Satoshi
AU  - Iyama S
FAU - Kato, Junji
AU  - Kato J
LA  - jpn
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Gan To Kagaku Ryoho
JT  - Gan to kagaku ryoho. Cancer & chemotherapy
JID - 7810034
RN  - 0 (Antibodies, Monoclonal, Murine-Derived)
RN  - 0 (Antineoplastic Agents)
RN  - 4F4X42SYQ6 (Rituximab)
SB  - IM
MH  - Aged, 80 and over
MH  - Antibodies, Monoclonal, Murine-Derived/*therapeutic use
MH  - Antineoplastic Agents/*therapeutic use
MH  - Biopsy
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphoma, Mantle-Cell/*diagnosis/*drug therapy
MH  - Male
MH  - Remission Induction
MH  - Rituximab
EDAT- 2012/10/16 06:00
MHDA- 2012/11/09 06:00
CRDT- 2012/10/16 06:00
PHST- 2012/10/16 06:00 [entrez]
PHST- 2012/10/16 06:00 [pubmed]
PHST- 2012/11/09 06:00 [medline]
PST - ppublish
SO  - Gan To Kagaku Ryoho. 2012 Oct;39(10):1547-50.