PMID- 23065507
OWN - NLM
STAT- MEDLINE
DCOM- 20131126
LR  - 20211021
IS  - 1592-8721 (Electronic)
IS  - 0390-6078 (Print)
IS  - 0390-6078 (Linking)
VI  - 98
IP  - 3
DP  - 2013 Mar
TI  - Plasma hepcidin levels and anemia in old age. The Leiden 85-Plus Study.
PG  - 448-54
LID - 10.3324/haematol.2012.068825 [doi]
AB  - Hepcidin, an important regulator of iron homeostasis, is suggested to be causally 
      related to anemia of inflammation. The aim of this study was to explore the role 
      of plasma hepcidin in anemia among older persons from the general population. The 
      Leiden 85-Plus Study is a population-based study of 85-year olds in Leiden, the 
      Netherlands. Eighty-five-year old inhabitants of Leiden were enrolled between 
      September 1997 and September 1999. At the age of 86, plasma hepcidin was 
      determined with time of flight mass spectrometry in 490 participants [160 (32.7%) 
      male, 114 (23.3%) with anemia]. Anemia was defined according to criteria of the 
      World Health Organization (hemoglobin level <13 g/dL for men and hemoglobin <12 
      g/dL for women). The median plasma hepcidin level was 3.0 nM [interquartile range 
      (IQR) 1.8-4.9]. We found strong correlations between plasma hepcidin and body 
      iron status, C-reactive protein and erythropoietin levels. Significantly higher 
      hepcidin levels were found in participants with anemia of inflammation (P<0.01), 
      in participants with anemia of kidney disease (P=0.01), and in participants with 
      unexplained anemia (P=0.01) than in participants without anemia. Participants 
      with iron-deficiency anemia had significantly lower plasma hepcidin levels than 
      participants without anemia (P<0.01). In conclusion, older persons with anemia of 
      inflammation have higher hepcidin levels than their counterparts without anemia. 
      The potential clinical value of hepcidin in future diagnostic algorithms for 
      anemia has to be explored.
FAU - den Elzen, Wendy P J
AU  - den Elzen WP
AD  - Department of Public Health and Primary Care, Leiden University Medical Center, 
      Leiden, The Netherlands. w.p.j.den_elzen@lumc.nl
FAU - de Craen, Anton J M
AU  - de Craen AJ
FAU - Wiegerinck, Erwin T
AU  - Wiegerinck ET
FAU - Westendorp, Rudi G J
AU  - Westendorp RG
FAU - Swinkels, Dorine W
AU  - Swinkels DW
FAU - Gussekloo, Jacobijn
AU  - Gussekloo J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121012
PL  - Italy
TA  - Haematologica
JT  - Haematologica
JID - 0417435
RN  - 0 (Hepcidins)
SB  - IM
MH  - Age Factors
MH  - Aged, 80 and over
MH  - Anemia/*blood/diagnosis/epidemiology
MH  - Comorbidity
MH  - Female
MH  - Hepcidins/*blood
MH  - Humans
MH  - Male
MH  - Netherlands/epidemiology
MH  - Population Surveillance
MH  - Prospective Studies
PMC - PMC3659927
EDAT- 2012/10/16 06:00
MHDA- 2013/12/16 06:00
PMCR- 2013/03/01
CRDT- 2012/10/16 06:00
PHST- 2012/10/16 06:00 [entrez]
PHST- 2012/10/16 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
PHST- 2013/03/01 00:00 [pmc-release]
AID - haematol.2012.068825 [pii]
AID - 0980448 [pii]
AID - 10.3324/haematol.2012.068825 [doi]
PST - ppublish
SO  - Haematologica. 2013 Mar;98(3):448-54. doi: 10.3324/haematol.2012.068825. Epub 
      2012 Oct 12.