PMID- 23067217
OWN - NLM
STAT- MEDLINE
DCOM- 20130618
LR  - 20221207
IS  - 0028-2685 (Print)
IS  - 0028-2685 (Linking)
VI  - 60
IP  - 1
DP  - 2013
TI  - Altered expression of ezrin, E-Cadherin and beta-Catenin in cervical neoplasia.
PG  - 56-61
LID - 10.4149/neo_2013_008 [doi]
AB  - High-grade cervical squamous intraepithelial lesions (CIN) as well as squamous 
      cell carcinoma and adenocarcinoma of the cervix are associated with persistent 
      high-risk human papillomavirus (HPV) infection. A number of cellular events play 
      a role in HPV pathogenesis and in the development of cervical lesions, including 
      alterations in cell adhesion and motility. The crucial plasma membrane - 
      cytoskeleton linker protein ezrin of the Ezrin-Radixin-Moesin (ERM) protein 
      family is involved in the regulation of cell morphology, cell adhesion and 
      invasion. Based on our previous work on ERM proteins we sought out to study the 
      expression of ezrin in cervical premalignant lesions. We also studied the 
      expression of E-cadherin and beta-catenin, which play an important role in 
      epithelial cell adhesion. We observed intensifying expression of ezrin along with 
      progressing grade of neoplasia. Ezrin staining was found to colocalize with p16 
      staining in high-risk HPV associated lesions. Expression of E-cadherin and 
      beta-catenin was found to be altered along with the severity of the lesion, similar 
      to ezrin. Enhanced expression of ezrin in cervical HPV associated lesions 
      suggests a role in the development of cervical neoplasia and cancer. Further 
      clinical evaluation should reveal the feasibility of ezrin as a biomarker for the 
      progression of cervical lesions.
FAU - Auvinen, E
AU  - Auvinen E
AD  - Department of Virology, University of Helsinki, Helsinki, Finland. 
      eeva.auvinen@helsinki.fi
FAU - Carpen, O
AU  - Carpen O
FAU - Korpela, T
AU  - Korpela T
FAU - Ronty, M
AU  - Ronty M
FAU - Vaheri, A
AU  - Vaheri A
FAU - Tarkkanen, J
AU  - Tarkkanen J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Slovakia
TA  - Neoplasma
JT  - Neoplasma
JID - 0377266
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (CTNNB1 protein, human)
RN  - 0 (Cadherins)
RN  - 0 (Cytoskeletal Proteins)
RN  - 0 (DNA, Viral)
RN  - 0 (beta Catenin)
RN  - 0 (ezrin)
SB  - IM
MH  - Adenocarcinoma/*metabolism/pathology/virology
MH  - Biomarkers, Tumor/*metabolism
MH  - Cadherins/*metabolism
MH  - Cervix Uteri/metabolism
MH  - Cytoskeletal Proteins/*metabolism
MH  - DNA, Viral/genetics
MH  - Female
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Neoplasm Grading
MH  - Papillomaviridae/genetics
MH  - Papillomavirus Infections/metabolism/pathology/virology
MH  - Prognosis
MH  - Uterine Cervical Neoplasms/*metabolism/pathology/virology
MH  - beta Catenin/*metabolism
MH  - Uterine Cervical Dysplasia/*metabolism/pathology/virology
EDAT- 2012/10/17 06:00
MHDA- 2013/06/19 06:00
CRDT- 2012/10/17 06:00
PHST- 2012/10/17 06:00 [entrez]
PHST- 2012/10/17 06:00 [pubmed]
PHST- 2013/06/19 06:00 [medline]
AID - 10.4149/neo_2013_008 [doi]
PST - ppublish
SO  - Neoplasma. 2013;60(1):56-61. doi: 10.4149/neo_2013_008.