PMID- 23068136
OWN - NLM
STAT- MEDLINE
DCOM- 20130524
LR  - 20191210
IS  - 1879-0003 (Electronic)
IS  - 0141-8130 (Linking)
VI  - 52
DP  - 2013 Jan
TI  - Sulfated modification can enhance antiviral activities of Achyranthes bidentata 
      polysaccharide against porcine reproductive and respiratory syndrome virus 
      (PRRSV) in vitro.
PG  - 21-4
LID - S0141-8130(12)00374-1 [pii]
LID - 10.1016/j.ijbiomac.2012.09.020 [doi]
AB  - Achyranthes bidentata polysaccharide (ABPS) was sulfated using the chlorosulfonic 
      acid-pyridine method. The UV-spectrum of sulfated ABPS (sABPS) was characterized 
      with two different absorbance peaks at 196.3 and 262.8 nm. FT-IR spectrum of 
      sABPS exhibited absorption bands at 1236.5 cm(-1) (asymmetrical S=O stretching 
      vibration) and 822.8 cm(-1) (symmetrical C-O-S vibration related to a C-O-SO(3) 
      group). Anti-PRRSV activities of sABPS were tested on MARC-145 cells by MTT 
      method. The results showed that sABPS exhibited significant antiviral activities 
      at lower concentrations in comparison with the non-modified ABPS treated cells, 
      indicating that sulfated modification could enhance antiviral activities of ABPS. 
      These findings may provide the potential value to develop a new-type drug against 
      PRRSV infection.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Liu, Chuanmin
AU  - Liu C
AD  - College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, PR China.
FAU - Chen, Huijuan
AU  - Chen H
FAU - Chen, Kun
AU  - Chen K
FAU - Gao, Yanfeng
AU  - Gao Y
FAU - Gao, Song
AU  - Gao S
FAU - Liu, Xiufan
AU  - Liu X
FAU - Li, Jingui
AU  - Li J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121012
PL  - Netherlands
TA  - Int J Biol Macromol
JT  - International journal of biological macromolecules
JID - 7909578
RN  - 0 (Antiviral Agents)
RN  - 0 (Polysaccharides)
SB  - IM
MH  - Achyranthes/*chemistry
MH  - Animals
MH  - *Antiviral Agents/chemistry/pharmacology
MH  - Cell Line
MH  - Chlorocebus aethiops
MH  - *Polysaccharides/chemistry/pharmacology
MH  - Porcine Reproductive and Respiratory Syndrome/*drug therapy
MH  - *Porcine respiratory and reproductive syndrome virus
MH  - Swine
EDAT- 2012/10/17 06:00
MHDA- 2013/05/28 06:00
CRDT- 2012/10/17 06:00
PHST- 2012/07/12 00:00 [received]
PHST- 2012/09/10 00:00 [revised]
PHST- 2012/09/25 00:00 [accepted]
PHST- 2012/10/17 06:00 [entrez]
PHST- 2012/10/17 06:00 [pubmed]
PHST- 2013/05/28 06:00 [medline]
AID - S0141-8130(12)00374-1 [pii]
AID - 10.1016/j.ijbiomac.2012.09.020 [doi]
PST - ppublish
SO  - Int J Biol Macromol. 2013 Jan;52:21-4. doi: 10.1016/j.ijbiomac.2012.09.020. Epub 
      2012 Oct 12.