PMID- 23069002
OWN - NLM
STAT- MEDLINE
DCOM- 20130314
LR  - 20170112
IS  - 0392-856X (Print)
IS  - 0392-856X (Linking)
VI  - 30
IP  - 6
DP  - 2012 Nov-Dec
TI  - Minor salivary gland biopsy and Sjogren's syndrome: comparative analysis of 
      biopsies among different Italian rheumatologic centers.
PG  - 929-33
AB  - OBJECTIVES: The minor salivary gland biopsy (MSGB) is widely considered an 
      important component of the diagnostic algorithm of primary Sjogren's syndrome 
      (pSS) and is mentioned in all the classification criteria sets for the disease. 
      The aim of this study, coordinated by the Italian Society of Rheumatology, was to 
      verify the inter-observer agreement on the evaluation of MSGB among different 
      experienced Italian rheumatologic centres, in order to better standardise the 
      diagnostic methodology. METHODS: Seven centres participated in the study, 
      providing a total of 50 MSGB samples. Each center blindly classified all the 
      samples according to the Chisholm and Mason (CM) grading. The results were 
      collected and analysed. RESULTS: The inter-observer agreement was satisfactory 
      when the samples were stratified as consistent and non-consistent with the final 
      diagnosis of pSS (median kappa =0.75; mean kappa =0.70). Nonetheless, significant 
      discrepancies in the histopathologic evaluation of MSGB emerged when the 
      agreement was assessed on the single scores. Considering the modal CM grading for 
      each sample as the correct grading, upon re-examination, a potential bias in the 
      final clinical diagnosis was detected in 7 out of 50 samples. CONCLUSIONS: This 
      study has shown significant discrepancies in the evaluation of MSGB among 
      different rheumatologic centres in the same country. Greater standardisation of 
      the procedure is clearly necessary, both to improve the diagnostic performance 
      and scientific communication.
FAU - Tavoni, Antonio Gaetano
AU  - Tavoni AG
AD  - Clinical Immunology Unit, Department of Internal Medicine, University of Pisa, 
      Pisa, Italy. a.tavoni@int.med.unipi.it
FAU - Baldini, Chiara
AU  - Baldini C
FAU - Bencivelli, Walter
AU  - Bencivelli W
FAU - Cavazzini, Luigi
AU  - Cavazzini L
FAU - Covelli, Michele
AU  - Covelli M
FAU - De Vita, Salvatore
AU  - De Vita S
FAU - Caporali, Roberto
AU  - Caporali R
FAU - Gerli, Roberto
AU  - Gerli R
FAU - Giansanti, Michele
AU  - Giansanti M
FAU - Govoni, Marcello
AU  - Govoni M
FAU - Donati, Valentina
AU  - Donati V
FAU - Montecucco, Carlo Maurizio
AU  - Montecucco CM
FAU - Morbini, Patrizia
AU  - Morbini P
FAU - Pilato, Francesco Paolo
AU  - Pilato FP
FAU - Resta, Leonardo
AU  - Resta L
FAU - Scott, Cathryn Anne
AU  - Scott CA
FAU - Mosca, Marta
AU  - Mosca M
FAU - Vitali, Claudio
AU  - Vitali C
FAU - Bombardieri, Stefano
AU  - Bombardieri S
CN  - Italian Study Group on Sjogren's Syndrome of the Italian Society of Rheumatology
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
DEP - 20121217
PL  - Italy
TA  - Clin Exp Rheumatol
JT  - Clinical and experimental rheumatology
JID - 8308521
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Biopsy/standards
MH  - Female
MH  - Humans
MH  - Italy
MH  - Male
MH  - Middle Aged
MH  - Observer Variation
MH  - Predictive Value of Tests
MH  - Reproducibility of Results
MH  - Retrospective Studies
MH  - Rheumatology/*methods/standards
MH  - Salivary Glands, Minor/*pathology
MH  - Severity of Illness Index
MH  - Sjogren's Syndrome/*pathology
MH  - *Tertiary Care Centers/standards
MH  - Young Adult
EDAT- 2012/10/17 06:00
MHDA- 2013/03/15 06:00
CRDT- 2012/10/17 06:00
PHST- 2012/09/24 00:00 [received]
PHST- 2012/10/02 00:00 [accepted]
PHST- 2012/10/17 06:00 [entrez]
PHST- 2012/10/17 06:00 [pubmed]
PHST- 2013/03/15 06:00 [medline]
AID - 6518 [pii]
PST - ppublish
SO  - Clin Exp Rheumatol. 2012 Nov-Dec;30(6):929-33. Epub 2012 Dec 17.