PMID- 23069755
OWN - NLM
STAT- MEDLINE
DCOM- 20131017
LR  - 20220331
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Linking)
VI  - 239
DP  - 2013 Jun 3
TI  - Brain-derived neurotrophic factor and glucocorticoids: reciprocal influence on 
      the central nervous system.
PG  - 157-72
LID - S0306-4522(12)01004-4 [pii]
LID - 10.1016/j.neuroscience.2012.09.073 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) has multiple roles in the central 
      nervous system (CNS), including maintaining cell survival and regulation of 
      synaptic function. In CNS neurons, BDNF triggers activation of phospholipase Cgamma 
      (PLCgamma), mitogen-activated protein/extracellular signal-regulated kinase 
      (MAPK/ERK), and phosphoinositide 3-kinase (PI3K)/Akt pathways, influencing 
      neuronal cells beneficially through these intracellular signaling cascades. There 
      is evidence to suggest that decreased BDNF expression or function is related to 
      the pathophysiology of brain diseases including psychiatric disorders. 
      Additionally, glucocorticoids, which are critical stress hormones, also influence 
      neuronal function in the CNS, and are putatively involved in the onset of 
      depression when levels are abnormally high. In animal models of depression, 
      changes in glucocorticoid levels, expression of glucocorticoid receptor (GR), and 
      alterations in BDNF signaling are observed. Interestingly, several studies using 
      in vivo and in vitro systems suggest that glucocorticoids interact with BDNF to 
      ultimately affect CNS function. In the present review, we provide an overview of 
      recent evidence concerning the interaction between BDNF and glucocorticoids.
CI  - Copyright (c) 2012 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Numakawa, T
AU  - Numakawa T
AD  - Department of Mental Disorder Research, National Institute of Neuroscience, 
      National Center of Neurology and Psychiatry (NCNP), Tokyo 187-8502, Japan. 
      numakawa@ncnp.go.jp
FAU - Adachi, N
AU  - Adachi N
FAU - Richards, M
AU  - Richards M
FAU - Chiba, S
AU  - Chiba S
FAU - Kunugi, H
AU  - Kunugi H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20121013
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Glucocorticoids)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Central Nervous System/*metabolism
MH  - Depression/metabolism
MH  - Glucocorticoids/*metabolism
MH  - Humans
MH  - Neurons/metabolism
EDAT- 2012/10/17 06:00
MHDA- 2013/10/18 06:00
CRDT- 2012/10/17 06:00
PHST- 2012/08/02 00:00 [received]
PHST- 2012/09/14 00:00 [revised]
PHST- 2012/09/29 00:00 [accepted]
PHST- 2012/10/17 06:00 [entrez]
PHST- 2012/10/17 06:00 [pubmed]
PHST- 2013/10/18 06:00 [medline]
AID - S0306-4522(12)01004-4 [pii]
AID - 10.1016/j.neuroscience.2012.09.073 [doi]
PST - ppublish
SO  - Neuroscience. 2013 Jun 3;239:157-72. doi: 10.1016/j.neuroscience.2012.09.073. 
      Epub 2012 Oct 13.