PMID- 23069951
OWN - NLM
STAT- MEDLINE
DCOM- 20130104
LR  - 20121016
IS  - 1538-3652 (Electronic)
IS  - 0003-987X (Linking)
VI  - 148
IP  - 10
DP  - 2012 Oct
TI  - Chromosomal aberrations by 4-color fluorescence in situ hybridization not 
      detected in Spitz nevi of older individuals.
PG  - 1152-6
LID - 10.1001/archdermatol.2012.2267 [doi]
AB  - OBJECTIVE: To investigate whether Spitz nevi with typical histopathological 
      features in older patients demonstrate chromosomal aberrations by 4-color 
      fluorescence in situ hybridization (FISH). DESIGN: Retrospective medical record 
      review, with prospective masked histopathological and cytogenetic analyses. 
      SETTING: University-affiliated dermatology and dermatopathology setting. 
      PATIENTS: Twenty-five patients 50 years or older with melanocytic nevi showing 
      histopathological features typical of Spitz nevi. MAIN OUTCOME MEASURES: Three 
      dermatopathologists masked to the patients' ages reviewed histopathological 
      sections of melanocytic lesions for features typical of Spitz nevi. FISH was 
      performed on samples with typical histopathological features by a 4-color FISH 
      probe set used for the evaluation of malignant melanocytic neoplasms. RESULTS: 
      None of the study cases showing histopathological features typical of Spitz nevi 
      had detectable chromosomal abnormalities by FISH. CONCLUSIONS: Spitz nevi in 
      older patients demonstrate molecular features similar to those of Spitz nevi in 
      younger age groups. The findings of normal karyotypes in combination with typical 
      histopathological features are reassuring of Spitz nevus diagnoses in older 
      patients and suggest no correlation of increased malignant potential with 
      advanced age per se.
FAU - Horst, Basil A
AU  - Horst BA
AD  - Department of Dermatology, Columbia University Medical Center, Vanderbilt Clinic, 
      Room 15-207, 630W168th St, New York, NY 10032, USA. bh2179@columbia.edu
FAU - Fang, Yuqiang
AU  - Fang Y
FAU - Silvers, David N
AU  - Silvers DN
FAU - Busam, Klaus J
AU  - Busam KJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Arch Dermatol
JT  - Archives of dermatology
JID - 0372433
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Child
MH  - *Chromosome Aberrations
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotype
MH  - Male
MH  - Middle Aged
MH  - Nevus, Epithelioid and Spindle Cell/*genetics/*pathology
MH  - Prospective Studies
MH  - Retrospective Studies
MH  - Single-Blind Method
MH  - Skin Neoplasms/*genetics/*pathology
EDAT- 2012/10/17 06:00
MHDA- 2013/01/05 06:00
CRDT- 2012/10/17 06:00
PHST- 2012/10/17 06:00 [entrez]
PHST- 2012/10/17 06:00 [pubmed]
PHST- 2013/01/05 06:00 [medline]
AID - 1379299 [pii]
AID - 10.1001/archdermatol.2012.2267 [doi]
PST - ppublish
SO  - Arch Dermatol. 2012 Oct;148(10):1152-6. doi: 10.1001/archdermatol.2012.2267.