PMID- 23070023
OWN - NLM
STAT- MEDLINE
DCOM- 20130910
LR  - 20231213
IS  - 1432-2072 (Electronic)
IS  - 0033-3158 (Print)
IS  - 0033-3158 (Linking)
VI  - 226
IP  - 2
DP  - 2013 Mar
TI  - Discriminative stimulus effects of N,N-diisopropyltryptamine.
PG  - 241-6
LID - 10.1007/s00213-012-2891-x [doi]
AB  - RATIONALE: Serotonergic hallucinogens such as (+)-lysergic acid diethylamide 
      (LSD) and dimethyltryptamine (DMT) produce distinctive visual effects, whereas 
      the synthetic hallucinogen N,N-diisopropyltryptamine (DiPT) is known for its 
      production of auditory distortions. OBJECTIVE: This study compares the 
      discriminative stimulus effects of DiPT to those of visual hallucinogens. 
      METHODS: Adult male rats were trained to discriminate DiPT (5 mg/kg, 15 min) from 
      saline under a FR10 schedule. A dose-effect and time course of DiPT's 
      discriminative stimulus effects were established. DMT, 
      (-)-2,5-dimethoxy-4-methylamphetamine (DOM), LSD, 
      (+/-)-methylenedioxymethamphetamine (MDMA), and (+)-methamphetamine were tested for 
      cross-substitution in DiPT-trained animals. RESULTS: Rats learned to discriminate 
      DiPT from saline in an average of 60 training sessions (30 drug and 30 saline). 
      DiPT (0.5-5 mg/kg) produced dose-dependent increases in drug-appropriate 
      responding (DAR) to 99 % (ED(50) = 2.47 mg/kg). Onset of the discriminative 
      stimulus effects was within 5 min, and the effects dissipated within 4 h. Full 
      substitution for the discriminative stimulus effects of DiPT occurred with LSD, 
      DOM, and MDMA. DMT only partially substituted for DiPT (65 % DAR), whereas 
      (+)-methamphetamine failed to substitute for DiPT (29 % DAR). CONCLUSIONS: The 
      discriminative stimulus effects of DiPT were similar those of a number of 
      synthetic hallucinogens, only partially similar to those of DMT, but not similar 
      to (+)-methamphetamine. The putative DiPT-induced auditory distortions do not 
      lead to discriminative stimulus effects distinguishable from other hallucinogens.
FAU - Carbonaro, Theresa M
AU  - Carbonaro TM
AD  - Department of Pharmacology and Neuroscience, University of North Texas Health 
      Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107-2699, USA.
FAU - Forster, Michael J
AU  - Forster MJ
FAU - Gatch, Michael B
AU  - Gatch MB
LA  - eng
GR  - HHSN271200700014C/DA/NIDA NIH HHS/United States
GR  - T32 AG020494/AG/NIA NIH HHS/United States
GR  - N01 DA78872/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20121016
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - 0 (Hallucinogens)
RN  - 0 (Tryptamines)
RN  - 14780-24-6 (N,N-diisopropyltryptamine)
RN  - 15588-95-1 (DOM 2,5-Dimethoxy-4-Methylamphetamine)
RN  - 44RAL3456C (Methamphetamine)
RN  - 8NA5SWF92O (Lysergic Acid Diethylamide)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - DOM 2,5-Dimethoxy-4-Methylamphetamine/pharmacology
MH  - Animals
MH  - Discrimination Learning/*drug effects
MH  - Dose-Response Relationship, Drug
MH  - Hallucinogens/*pharmacology
MH  - Lysergic Acid Diethylamide/pharmacology
MH  - Male
MH  - Methamphetamine/pharmacology
MH  - N-Methyl-3,4-methylenedioxyamphetamine/pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Tryptamines/*pharmacology
PMC - PMC3577941
MID - NIHMS415148
EDAT- 2012/10/17 06:00
MHDA- 2013/09/11 06:00
PMCR- 2014/03/01
CRDT- 2012/10/17 06:00
PHST- 2012/08/08 00:00 [received]
PHST- 2012/10/03 00:00 [accepted]
PHST- 2012/10/17 06:00 [entrez]
PHST- 2012/10/17 06:00 [pubmed]
PHST- 2013/09/11 06:00 [medline]
PHST- 2014/03/01 00:00 [pmc-release]
AID - 10.1007/s00213-012-2891-x [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 2013 Mar;226(2):241-6. doi: 10.1007/s00213-012-2891-x. 
      Epub 2012 Oct 16.