PMID- 23071146
OWN - NLM
STAT- MEDLINE
DCOM- 20130122
LR  - 20220410
IS  - 1942-0080 (Electronic)
IS  - 1941-9651 (Linking)
VI  - 5
IP  - 6
DP  - 2012 Nov
TI  - Myocardial tissue characterization using magnetic resonance noncontrast t1 
      mapping in hypertrophic and dilated cardiomyopathy.
PG  - 726-33
LID - 10.1161/CIRCIMAGING.112.976738 [doi]
AB  - BACKGROUND: Noncontrast magnetic resonance T1 mapping reflects a composite of 
      both intra- and extracellular signal. We hypothesized that noncontrast T1 mapping 
      can characterize the myocardium beyond that achieved by the well-established late 
      gadolinium enhancement (LGE) technique (which detects focal fibrosis) in both 
      hypertrophic (HCM) and dilated (DCM) cardiomyopathy, by detecting both diffuse 
      and focal fibrosis. METHODS AND RESULTS: Subjects underwent Cardiovascular 
      Magnetic Resonance imaging at 3T (28 HCM, 18 DCM, and 12 normals). Matching 
      short-axis slices were acquired for cine, T1 mapping, and LGE imaging (0.1 
      mmol/kg). Circumferential strain was measured in the midventricular slice, and 
      (31)P magnetic resonance spectroscopy was acquired for the septum of the 
      midventricular slice. Mean T1 relaxation time was increased in HCM and DCM (HCM 
      1209+/-28 ms, DCM 1225+/-42 ms, normal 1178+/-13 ms, P<0.05). There was a weak 
      correlation between mean T1 and LGE (r=0.32, P<0.001). T1 values were higher in 
      segments with LGE than in those without (HCM with LGE 1228+/-41 ms versus no LGE 
      1192+/-79 ms, P<0.01; DCM with LGE 1254+/-73 ms versus no LGE 1217+/-52 ms, P<0.01). 
      However, in both HCM and DCM, even in segments unaffected by LGE, T1 values were 
      significantly higher than normal (P<0.01). T1 values correlated with disease 
      severity, being increased as wall thickness increased in HCM; conversely, in DCM, 
      T1 values were highest in the thinnest myocardial segments. T1 values also 
      correlated significantly with circumferential strain (r=0.42, P<0.01). 
      Interestingly, this correlation remained statistically significant even for the 
      slices without LGE (r=0.56, P=0.04). Finally, there was also a statistically 
      significant negative correlation between T1 values and phosphocreatine/adenosine 
      triphosphate ratios (r=-0.59, P<0.0001). CONCLUSIONS: In HCM and DCM, noncontrast 
      T1 mapping detects underlying disease processes beyond those assessed by LGE in 
      relatively low-risk individuals.
FAU - Dass, Sairia
AU  - Dass S
AD  - University of Oxford Centre for Clinical Magnetic Resonance Research, UK.
FAU - Suttie, Joseph J
AU  - Suttie JJ
FAU - Piechnik, Stefan K
AU  - Piechnik SK
FAU - Ferreira, Vanessa M
AU  - Ferreira VM
FAU - Holloway, Cameron J
AU  - Holloway CJ
FAU - Banerjee, Rajarshi
AU  - Banerjee R
FAU - Mahmod, Masliza
AU  - Mahmod M
FAU - Cochlin, Lowri
AU  - Cochlin L
FAU - Karamitsos, Theodoros D
AU  - Karamitsos TD
FAU - Robson, Matthew D
AU  - Robson MD
FAU - Watkins, Hugh
AU  - Watkins H
FAU - Neubauer, Stefan
AU  - Neubauer S
LA  - eng
GR  - RG/07/012/24110/BHF_/British Heart Foundation/United Kingdom
GR  - G0700796/MRC_/Medical Research Council/United Kingdom
GR  - DH_/Department of Health/United Kingdom
GR  - FS/07/030/BHF_/British Heart Foundation/United Kingdom
GR  - 090532/Wellcome Trust/United Kingdom
GR  - G0900883/MRC_/Medical Research Council/United Kingdom
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121015
PL  - United States
TA  - Circ Cardiovasc Imaging
JT  - Circulation. Cardiovascular imaging
JID - 101479935
RN  - 0 (Contrast Media)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
CIN - Circ Cardiovasc Imaging. 2013 Mar 1;6(2):e1. PMID: 23512783
CIN - Circ Cardiovasc Imaging. 2013 Mar 1;6(2):e2. PMID: 23512784
MH  - Cardiomyopathy, Dilated/*diagnosis
MH  - Cardiomyopathy, Hypertrophic/*diagnosis
MH  - Contrast Media
MH  - Female
MH  - *Gadolinium DTPA
MH  - Humans
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - Male
MH  - Middle Aged
MH  - Myocardium/*pathology
MH  - Severity of Illness Index
EDAT- 2012/10/17 06:00
MHDA- 2013/01/23 06:00
CRDT- 2012/10/17 06:00
PHST- 2012/10/17 06:00 [entrez]
PHST- 2012/10/17 06:00 [pubmed]
PHST- 2013/01/23 06:00 [medline]
AID - CIRCIMAGING.112.976738 [pii]
AID - 10.1161/CIRCIMAGING.112.976738 [doi]
PST - ppublish
SO  - Circ Cardiovasc Imaging. 2012 Nov;5(6):726-33. doi: 
      10.1161/CIRCIMAGING.112.976738. Epub 2012 Oct 15.