PMID- 23071161
OWN - NLM
STAT- MEDLINE
DCOM- 20130212
LR  - 20221207
IS  - 1945-7197 (Electronic)
IS  - 0021-972X (Linking)
VI  - 97
IP  - 12
DP  - 2012 Dec
TI  - High frequency of HLA B62 in fulminant type 1 diabetes with the drug-induced 
      hypersensitivity syndrome.
PG  - E2277-81
LID - 10.1210/jc.2012-2054 [doi]
AB  - CONTEXT: Fulminant type 1 diabetes (FT1D) is a subtype of type 1 diabetes 
      characterized by an extremely abrupt onset. FT1D cases associated with the 
      drug-induced hypersensitivity syndrome (DIHS) have recently been reported. 
      OBJECTIVE: The clinical characteristics of FT1D associated with DIHS were 
      investigated in this study. METHODS: Case reports of FT1D associated with DIHS in 
      Japanese subjects were collected and analyzed by means of a questionnaire to the 
      authors. A nationwide questionnaire survey was administered to dermatology 
      specialists, concerning the frequency of FT1D associated with DIHS. RESULTS: In 
      15 case reports, the mean age at onset of FT1D was 53.4 yr and the mean time for 
      its development from the onset of DIHS was 39.9 d. A higher frequency of human 
      leukocyte antigen (HLA) B62, but not of HLA DR was found in FT1D with DIHS than 
      that for cases without DIHS (P < 0.001). The reactivation of herpes virus 6 and 
      cytomegalovirus was detected in 11 and four cases, respectively. Among 746 
      patients with DIHS in the nationwide survey, four developed FT1D during a 3-yr 
      period. The frequency of FT1D in DIHS (0.54%) was much higher than that in the 
      general Japanese population (0.010%). CONCLUSIONS: The clinical characteristics 
      of FT1D with DIHS were similar to those without DIHS except for the high 
      frequency of HLA B62, which may be involved in the pathogenesis of FT1D with 
      DIHS. Because the frequency was much higher than that in the general Japanese 
      population, FT1D should be kept in mind when DIHS develops.
FAU - Onuma, Hiroshi
AU  - Onuma H
AD  - Department of Molecular and Genetic Medicine, Ehime University Graduate School of 
      Medicine, To-on, Ehime, 791-0295 Japan. onuma@m.ehime-u.ac.jp
FAU - Tohyama, Mikiko
AU  - Tohyama M
FAU - Imagawa, Akihisa
AU  - Imagawa A
FAU - Hanafusa, Toshiaki
AU  - Hanafusa T
FAU - Kobayashi, Tetsuro
AU  - Kobayashi T
FAU - Kano, Yoko
AU  - Kano Y
FAU - Ohashi, Jun
AU  - Ohashi J
FAU - Hashimoto, Koji
AU  - Hashimoto K
FAU - Osawa, Haruhiko
AU  - Osawa H
FAU - Makino, Hideichi
AU  - Makino H
CN  - Japan Diabetes Society Committee on Type 1 Diabetes Mellitus Research
CN  - Japanese Dermatological Association
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20121015
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (HLA-B Antigens)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Asian People/genetics
MH  - Data Collection
MH  - Diabetes Mellitus, Type 1/complications/*genetics/pathology
MH  - Disease Progression
MH  - Drug Hypersensitivity/complications/*genetics
MH  - Female
MH  - Gene Frequency
MH  - HLA-B Antigens/*genetics/physiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Syndrome
MH  - Young Adult
EDAT- 2012/10/17 06:00
MHDA- 2013/02/13 06:00
CRDT- 2012/10/17 06:00
PHST- 2012/10/17 06:00 [entrez]
PHST- 2012/10/17 06:00 [pubmed]
PHST- 2013/02/13 06:00 [medline]
AID - jc.2012-2054 [pii]
AID - 10.1210/jc.2012-2054 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2012 Dec;97(12):E2277-81. doi: 10.1210/jc.2012-2054. 
      Epub 2012 Oct 15.