PMID- 23072660 OWN - NLM STAT- MEDLINE DCOM- 20131112 LR - 20211026 IS - 1179-2027 (Electronic) IS - 1170-7690 (Linking) VI - 30 IP - 12 DP - 2012 Dec 1 TI - A systematic review and critical assessment of health state utilities: weight change and type 2 diabetes mellitus. PG - 1133-43 LID - 10.2165/11599420-000000000-00000 [doi] AB - OBJECTIVE: The study aimed to conduct a systematic literature search to identify health state utilities for weight change in type 2 diabetes mellitus (T2DM) and to review those values for appropriateness for inclusion in a submission to the National Institute for Health and Clinical Excellence (NICE). METHODS: The search was conducted using keywords and Medical Subject Heading (MeSH) terms designed to exhaustively capture health state utility values across a variety of known economic, health technology assessment and peer-reviewed publication databases. The values were then critically reviewed from the perspective of the NICE reference case (2008 methods guide). RESULTS: The search resulted in a large number of repeat references across databases suggesting good sensitivity. Thirty-three articles were selected for inclusion and subjected to a critical review including their methodological quality, symmetry with the NICE reference case, sample size and country source. This critical review led to a shortlist of nine utility studies, all of which had potential for inclusion in cost-utility models or a meta-analysis. CONCLUSIONS: A relatively large number of utilities have been collected in weight change and T2DM. Many of these utility values are not suitable for inclusion in a NICE submission. A better way of reviewing the methodological quality of utilities is needed. FAU - Doyle, Scott AU - Doyle S AD - Oxford Outcomes, Oxford, UK. FAU - Lloyd, Andrew AU - Lloyd A FAU - Moore, Lee AU - Moore L FAU - Ray, Joshua AU - Ray J FAU - Gray, Alastair AU - Gray A LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review PT - Systematic Review PL - New Zealand TA - Pharmacoeconomics JT - PharmacoEconomics JID - 9212404 MH - Body Weight MH - Cost-Benefit Analysis MH - Diabetes Mellitus, Type 2/economics/*physiopathology MH - *Health Status MH - Humans MH - *Models, Economic MH - Technology Assessment, Biomedical EDAT- 2012/10/18 06:00 MHDA- 2013/11/13 06:00 CRDT- 2012/10/18 06:00 PHST- 2012/10/18 06:00 [entrez] PHST- 2012/10/18 06:00 [pubmed] PHST- 2013/11/13 06:00 [medline] AID - 10.2165/11599420-000000000-00000 [doi] PST - ppublish SO - Pharmacoeconomics. 2012 Dec 1;30(12):1133-43. doi: 10.2165/11599420-000000000-00000.