PMID- 23072749
OWN - NLM
STAT- MEDLINE
DCOM- 20130221
LR  - 20211021
IS  - 1559-7016 (Electronic)
IS  - 0271-678X (Print)
IS  - 0271-678X (Linking)
VI  - 33
IP  - 1
DP  - 2013 Jan
TI  - Immunologic privilege in the central nervous system and the blood-brain barrier.
PG  - 13-21
LID - 10.1038/jcbfm.2012.153 [doi]
AB  - The brain is in many ways an immunologically and pharmacologically privileged 
      site. The blood-brain barrier (BBB) of the cerebrovascular endothelium and its 
      participation in the complex structure of the neurovascular unit (NVU) restrict 
      access of immune cells and immune mediators to the central nervous system (CNS). 
      In pathologic conditions, very well-organized immunologic responses can develop 
      within the CNS, raising important questions about the real nature and the 
      intrinsic and extrinsic regulation of this immune privilege. We assess the 
      interactions of immune cells and immune mediators with the BBB and NVU in 
      neurologic disease, cerebrovascular disease, and intracerebral tumors. The goals 
      of this review are to outline key scientific advances and the status of the 
      science central to both the neuroinflammation and CNS barriers fields, and 
      highlight the opportunities and priorities in advancing brain barriers research 
      in the context of the larger immunology and neuroscience disciplines. This review 
      article was developed from reports presented at the 2011 Annual Blood-Brain 
      Barrier Consortium Meeting.
FAU - Muldoon, Leslie L
AU  - Muldoon LL
AD  - Department of Neurology, Oregon Health and Science University, Portland, OR, USA.
FAU - Alvarez, Jorge I
AU  - Alvarez JI
FAU - Begley, David J
AU  - Begley DJ
FAU - Boado, Ruben J
AU  - Boado RJ
FAU - Del Zoppo, Gregory J
AU  - Del Zoppo GJ
FAU - Doolittle, Nancy D
AU  - Doolittle ND
FAU - Engelhardt, Britta
AU  - Engelhardt B
FAU - Hallenbeck, John M
AU  - Hallenbeck JM
FAU - Lonser, Russell R
AU  - Lonser RR
FAU - Ohlfest, John R
AU  - Ohlfest JR
FAU - Prat, Alexandre
AU  - Prat A
FAU - Scarpa, Maurizio
AU  - Scarpa M
FAU - Smeyne, Richard J
AU  - Smeyne RJ
FAU - Drewes, Lester R
AU  - Drewes LR
FAU - Neuwelt, Edward A
AU  - Neuwelt EA
LA  - eng
GR  - R01 NS075840/NS/NINDS NIH HHS/United States
GR  - R13 NS076353/NS/NINDS NIH HHS/United States
GR  - R01 NS026945/NS/NINDS NIH HHS/United States
GR  - R37 NS038710/NS/NINDS NIH HHS/United States
GR  - R01 NS053716/NS/NINDS NIH HHS/United States
GR  - 9R13NS076353/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20121017
PL  - United States
TA  - J Cereb Blood Flow Metab
JT  - Journal of cerebral blood flow and metabolism : official journal of the 
      International Society of Cerebral Blood Flow and Metabolism
JID - 8112566
SB  - IM
MH  - Animals
MH  - Blood-Brain Barrier/*immunology
MH  - Central Nervous System Diseases/*immunology
MH  - Endothelium, Vascular/immunology
MH  - Humans
MH  - Neurogenic Inflammation/*immunology
MH  - Neuroimaging
MH  - Neuroimmunomodulation
PMC - PMC3597357
EDAT- 2012/10/18 06:00
MHDA- 2013/02/22 06:00
PMCR- 2014/01/01
CRDT- 2012/10/18 06:00
PHST- 2012/10/18 06:00 [entrez]
PHST- 2012/10/18 06:00 [pubmed]
PHST- 2013/02/22 06:00 [medline]
PHST- 2014/01/01 00:00 [pmc-release]
AID - jcbfm2012153 [pii]
AID - 10.1038/jcbfm.2012.153 [doi]
PST - ppublish
SO  - J Cereb Blood Flow Metab. 2013 Jan;33(1):13-21. doi: 10.1038/jcbfm.2012.153. Epub 
      2012 Oct 17.