PMID- 23074899
OWN - NLM
STAT- MEDLINE
DCOM- 20121105
LR  - 20161125
IS  - 1934-578X (Print)
IS  - 1555-9475 (Linking)
VI  - 7
IP  - 9
DP  - 2012 Sep
TI  - Antifungal activity of hydrochloride salts of tylophorinidine and tylophorinine.
PG  - 1171-2
AB  - The antimicrobial efficacy of two phenanthroindolizidine alkaloids, 
      tylophorinidine hydrochloride (TdnH) and tylophorinine hydrochloride (TnnH), 
      isolated from the plant Tylophora indica (local name, Antamul) was evaluated. 
      These were screened for in vitro antifungal and antibacterial activities. Both 
      compounds exhibited potent antifungal activity displaying minimum inhibitory 
      concentrations (MIC) in the range of 2-4 microg/mL for TdnH and 0.6-2.5 microg/mL 
      for TnnH against Candida species.
FAU - Dhiman, Mini
AU  - Dhiman M
AD  - Special Projects Analytical Chemistry, Piramal Healthcare Limited, Mumbai-400063, 
      India.
FAU - Parab, Rajashri R
AU  - Parab RR
FAU - Manju, Sreedharannair L
AU  - Manju SL
FAU - Desai, Dattatraya C
AU  - Desai DC
FAU - Mahajan, Girish B
AU  - Mahajan GB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Nat Prod Commun
JT  - Natural product communications
JID - 101477873
RN  - 0 (Alkaloids)
RN  - 0 (Antifungal Agents)
RN  - 0 (Indolizidines)
RN  - 0 (Isoquinolines)
RN  - 0 (Phenanthrenes)
RN  - 0 (Plant Extracts)
RN  - 0 (tylophorinine)
RN  - 32523-69-6 (tylophorinidine)
SB  - IM
MH  - Alkaloids/*pharmacology
MH  - Antifungal Agents/*pharmacology
MH  - Indolizidines
MH  - Isoquinolines/*pharmacology
MH  - Microbial Sensitivity Tests
MH  - Phenanthrenes
MH  - Plant Extracts/pharmacology
MH  - Tylophora/chemistry
EDAT- 2012/10/19 06:00
MHDA- 2012/11/06 06:00
CRDT- 2012/10/19 06:00
PHST- 2012/10/19 06:00 [entrez]
PHST- 2012/10/19 06:00 [pubmed]
PHST- 2012/11/06 06:00 [medline]
PST - ppublish
SO  - Nat Prod Commun. 2012 Sep;7(9):1171-2.