PMID- 23075726
OWN - NLM
STAT- MEDLINE
DCOM- 20131119
LR  - 20171116
IS  - 2542-5641 (Electronic)
IS  - 0366-6999 (Linking)
VI  - 125
IP  - 20
DP  - 2012 Oct
TI  - Effects of phlorizin on vascular complications in diabetes db/db mice.
PG  - 3692-6
AB  - BACKGROUND: Diabetic macrovascular complications are important causes of 
      cardiovascular and cerebrovascular diseases and also one of the major causes of 
      morbidity and mortality in patients with type 2 diabetes mellitus (T2DM). 
      Phlorizin has been reported to be effective in reducing the blood glucose level 
      in diabetic mellitus, while little is known about its effects on vascular 
      complications. This study aimed to observe the effects of phlorizin on the aorta 
      of diabetes db/db mice and explore its mechanism. METHODS: Diabetic db/db mice (n 
      = 16) and age-matched db/m mice (n = 8) were divided into three groups: normal 
      control group (CC group, db/m mice, n = 8), untreated diabetic group (DM group, 
      db/db mice, n = 8) and diabetic group treated by phlorizin (DMT group, db/db 
      mice, n = 8). Phlorizin (20 mg/kg body weight) was given in normal saline 
      solution intragastrically for 10 weeks. Animals were weighed weekly. At the 10th 
      weekend, all mice were fasted overnight and then sacrificed. Fasting blood was 
      collected, and the aortas were dissected. The blood samples were analyzed for 
      fasting blood glucose (FBG), serum advanced glycation end products (AGEs), 
      malondialdehyde (MDA) and superoxide dismutase (SOD) activity, the aortic 
      ultrastructure was studied. RESULTS: The weight and serum concentration of FBG, 
      AGEs, and MDA in the DM group were higher than that in the CC group (P < 0.01), 
      and they were significantly lower in the DMT group (P < 0.05). Serum SOD activity 
      was lower than that in the CC group (P < 0.01), and it is significantly higher in 
      the DMT group (P < 0.05). The severity of aorta damage in the DMT group was less 
      than that in the DM group. CONCLUSIONS: Phlorizin protected the db/db mice from 
      diabetic macrovascular complications, attributed to the decreasing of blood 
      glucose and AGEs level, and its antioxidant potential. This study may provide a 
      new natural medicine for treating diabetic macrovascular complications.
FAU - Shen, Lin
AU  - Shen L
AD  - Department of Geriatrics, Qilu Hospital of Shandong University, Jinan, Shandong 
      250012, China.
FAU - You, Bei-An
AU  - You BA
FAU - Gao, Hai-Qing
AU  - Gao HQ
FAU - Li, Bao-Ying
AU  - Li BY
FAU - Yu, Fei
AU  - Yu F
FAU - Pei, Fei
AU  - Pei F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Chin Med J (Engl)
JT  - Chinese medical journal
JID - 7513795
RN  - 0 (Blood Glucose)
RN  - 0 (Glycation End Products, Advanced)
RN  - CU9S17279X (Phlorhizin)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
SB  - IM
MH  - Animals
MH  - Aorta, Thoracic/pathology
MH  - Blood Glucose/analysis
MH  - Diabetic Angiopathies/*drug therapy/pathology
MH  - Glycation End Products, Advanced/metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Phlorhizin/*therapeutic use
MH  - Superoxide Dismutase/metabolism
EDAT- 2012/10/19 06:00
MHDA- 2013/11/20 06:00
CRDT- 2012/10/19 06:00
PHST- 2012/10/19 06:00 [entrez]
PHST- 2012/10/19 06:00 [pubmed]
PHST- 2013/11/20 06:00 [medline]
PST - ppublish
SO  - Chin Med J (Engl). 2012 Oct;125(20):3692-6.