PMID- 23075895
OWN - NLM
STAT- MEDLINE
DCOM- 20130130
LR  - 20121018
IS  - 0001-5547 (Print)
IS  - 0001-5547 (Linking)
VI  - 56
IP  - 5
DP  - 2012
TI  - Distinguishing urothelial carcinoma in the upper urinary tract from benign 
      diseases with hematuria using FISH.
PG  - 533-8
LID - 10.1159/000341622 [doi]
AB  - OBJECTIVE: The aims of this study were to evaluate the clinical utility of a 
      fluorescence in situ hybridization (FISH) assay as a non-invasive molecular test 
      to distinguish urothelial carcinoma (UC) in the upper urinary tract (UUT) from 
      benign lesions presenting with hematuria. STUDY DESIGN: The chromosomal 
      abnormalities of chromosomes 3, 7, 17 and 9 (p16) in hematuria specimens from 34 
      patients with UUT-UC and 33 patients with benign disorders were detected using a 
      set of fluorescently labeled DNA probes. The abnormalities of the chromosomes 
      were determined and analyzed between UUT-UC and benign disorders. RESULTS: 
      Chromosomal abnormalities were detected in 25 of 34 (73.5%) patients with UUT-UC 
      and in 2 of 33 (6.1%) patients with benign disorders (p < 0.001). CONCLUSIONS: 
      FISH of chromosomes 3, 7, 9 and 17 performed on exfoliated cells from voided 
      urine specimens may serve as a non-invasive tool to distinguish UUT-UC from 
      benign disorders presenting with hematuria.
CI  - Copyright (c) 2012 S. Karger AG, Basel.
FAU - Wang, Jiandong
AU  - Wang J
AD  - Department of Pathology, Nanjing Jinling Hospital, Nanjing University School of 
      Medicine, Nanjing, PR China.
FAU - Wu, Jinrong
AU  - Wu J
FAU - Peng, Libo
AU  - Peng L
FAU - Tu, Pin
AU  - Tu P
FAU - Li, Wanchun
AU  - Li W
FAU - Liu, Leilei
AU  - Liu L
FAU - Cheng, Wen
AU  - Cheng W
FAU - Wang, Xuan
AU  - Wang X
FAU - Zhou, Shuigen
AU  - Zhou S
FAU - Shi, Shanshan
AU  - Shi S
FAU - Ma, Henghui
AU  - Ma H
FAU - Lu, Guangming
AU  - Lu G
FAU - Zhou, Xiaojun
AU  - Zhou X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120927
PL  - Switzerland
TA  - Acta Cytol
JT  - Acta cytologica
JID - 0370307
RN  - 0 (Cyclin-Dependent Kinase Inhibitor p16)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Transitional Cell/diagnosis/*genetics
MH  - Chromosome Aberrations
MH  - Chromosomes, Human, Pair 17/genetics
MH  - Chromosomes, Human, Pair 3/genetics
MH  - Chromosomes, Human, Pair 7/genetics
MH  - Cyclin-Dependent Kinase Inhibitor p16/genetics
MH  - Diagnosis, Differential
MH  - Female
MH  - Hematuria/diagnosis/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/*methods
MH  - Loss of Heterozygosity
MH  - Male
MH  - Middle Aged
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Urologic Diseases/diagnosis/*genetics
MH  - Urologic Neoplasms/diagnosis/*genetics
MH  - Young Adult
EDAT- 2012/10/19 06:00
MHDA- 2013/01/31 06:00
CRDT- 2012/10/19 06:00
PHST- 2012/05/23 00:00 [received]
PHST- 2012/07/04 00:00 [accepted]
PHST- 2012/10/19 06:00 [entrez]
PHST- 2012/10/19 06:00 [pubmed]
PHST- 2013/01/31 06:00 [medline]
AID - 000341622 [pii]
AID - 10.1159/000341622 [doi]
PST - ppublish
SO  - Acta Cytol. 2012;56(5):533-8. doi: 10.1159/000341622. Epub 2012 Sep 27.