PMID- 2307613
OWN - NLM
STAT- MEDLINE
DCOM- 19900403
LR  - 20131121
IS  - 0003-1488 (Print)
IS  - 0003-1488 (Linking)
VI  - 196
IP  - 5
DP  - 1990 Mar 1
TI  - Effect of dietary iron content on hematologic and other measures of iron adequacy 
      in dogs.
PG  - 749-53
AB  - Eighteen 9- to 10-week old Beagles were fed casein-based diets (4,710 kcal of 
      metabolizable energy/kg of body weight) containing either 12, 80, or 160 mg of 
      iron/kg of diet. Growth and feed consumption were monitored throughout the 47-day 
      study. Hematocrit (Hct), hemoglobin (Hb) concentration, mean corpuscular volume 
      (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin 
      concentration (MCHC), RBC numbers, erythrocyte protoporphyrin (EP) concentration, 
      serum iron concentration, serum total iron-binding capacity (TIBC), and serum 
      ferritin concentration were determined weekly. Growth rate and feed efficiency 
      were not significantly influenced by dietary iron content. At 14 days, Hb 
      concentration, Hct, MCV, MCH, RBC numbers, and serum iron concentration were 
      significantly (P less than 0.05) lower in dogs fed the 12 mg/kg diet, and 
      remained significantly low for the remainder of the study. Erythrocyte 
      protoporphyrin concentration increased significantly (P less than 0.05) by 14 
      days in dogs fed the basal diet, and remained significantly high relative to that 
      in dogs of the other dietary groups for the remainder of the study. Serum 
      ferritin concentration decreased in dogs of the group fed the basal diet, with a 
      significant (P less than 0.05) difference beyond day 42. Differences in Hct, MCH, 
      MCV, or hemoglobin, serum iron, serum ferritin, or EP concentration were not 
      found between groups fed 80 and 160 mg of iron/kg of diet. Liver nonheme iron 
      content was significantly (P less than 0.05) affected by dietary iron content.
FAU - Weeks, B R
AU  - Weeks BR
AD  - Department of Pathology, College of Veterinary Medicine, Kansas State University, 
      Manhattan 66506.
FAU - Smith, J E
AU  - Smith JE
FAU - Stadler, C K
AU  - Stadler CK
LA  - eng
GR  - HL01877/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Am Vet Med Assoc
JT  - Journal of the American Veterinary Medical Association
JID - 7503067
RN  - 0 (Hemoglobins)
RN  - 9007-73-2 (Ferritins)
RN  - E1UOL152H7 (Iron)
SB  - IM
MH  - Animals
MH  - *Diet
MH  - Dogs/*blood/growth & development
MH  - Eating
MH  - Erythrocyte Count/veterinary
MH  - Erythrocyte Indices
MH  - Female
MH  - Ferritins/blood
MH  - Hematocrit/veterinary
MH  - Hemoglobins/analysis
MH  - Iron/*administration & dosage/blood
MH  - Male
MH  - Random Allocation
EDAT- 1990/03/01 00:00
MHDA- 1990/03/01 00:01
CRDT- 1990/03/01 00:00
PHST- 1990/03/01 00:00 [pubmed]
PHST- 1990/03/01 00:01 [medline]
PHST- 1990/03/01 00:00 [entrez]
PST - ppublish
SO  - J Am Vet Med Assoc. 1990 Mar 1;196(5):749-53.