PMID- 23076217
OWN - NLM
STAT- MEDLINE
DCOM- 20130912
LR  - 20220331
IS  - 1880-3873 (Electronic)
IS  - 1340-3478 (Linking)
VI  - 20
IP  - 2
DP  - 2013
TI  - Small dense low-density lipoproteins cholesterol can predict incident 
      cardiovascular disease in an urban Japanese cohort: the Suita study.
PG  - 195-203
AB  - AIM: Several lines of evidence indicate that small dense low-density lipoproteins 
      (sd-LDL) are more atherogenic than large buoyant LDL; however, few prospective 
      studies have addressed the role of sd-LDL in cardiovascular disease (CVD). We 
      therefore examined the association between sd-LDL cholesterol (sd-LDL-C) and CVD 
      in a Japanese cohort. METHODS: An 11.7-year prospective study was performed using 
      a general population aged 30-79 without a history of cardiovascular disease. 
      Direct LDL-C and sd-LDL-C were measured in samples from 2034 participants (968 
      men and 1066 women). RESULTS: During the follow-up period, there were 116 
      incident cases of CVD. The multivariable-adjusted hazard ratios (HRs) of sd-LDL-C 
      for CVD were calculated using a proportional hazards regression model after 
      adjusting for age, hypertension, diabetes, use of lipid-lowering drugs, body mass 
      index, and current smoking and alcohol drinking, and found that increasing 
      quartiles of sd-LDL-C were associated with increased risk of CVD. We also 
      determined that age and sex-adjusted HRs per 10 mg/dL of sd-LDL-C and HRs for 
      CVD, stroke, cerebral infarction, and coronary artery disease were 1.21 (95% CI: 
      1.12-1.31), 1.17 (95% CI: 1.05-1.30), 1.15 (95% CI: 1.00-1.33), and 1.29 (95% CI: 
      1.14-1.45), respectively. CONCLUSIONS: It was demonstrated that sd-LDL-C was 
      significantly associated with CVD in a Japanese population, providing evidence of 
      sd-LDL-C as an important biomarker to predict CVD.
FAU - Arai, Hidenori
AU  - Arai H
AD  - Department of Human Health Sciences, Kyoto University Graduate School of 
      Medicine.
FAU - Kokubo, Yoshihiro
AU  - Kokubo Y
FAU - Watanabe, Makoto
AU  - Watanabe M
FAU - Sawamura, Tatsuya
AU  - Sawamura T
FAU - Ito, Yasuki
AU  - Ito Y
FAU - Minagawa, Asako
AU  - Minagawa A
FAU - Okamura, Tomonori
AU  - Okamura T
FAU - Miyamato, Yoshihiro
AU  - Miyamato Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121017
PL  - Japan
TA  - J Atheroscler Thromb
JT  - Journal of atherosclerosis and thrombosis
JID - 9506298
RN  - 0 (Biomarkers)
RN  - 0 (Cholesterol, LDL)
RN  - 0 (Lipoproteins)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Biomarkers/blood
MH  - Body Mass Index
MH  - Cardiovascular Diseases/*blood/*diagnosis/epidemiology
MH  - Cholesterol, LDL/*blood
MH  - Female
MH  - Humans
MH  - Japan/epidemiology
MH  - Lipoproteins/metabolism
MH  - Male
MH  - Middle Aged
MH  - Proportional Hazards Models
MH  - Prospective Studies
MH  - Reference Values
MH  - Risk Factors
MH  - Urban Population
EDAT- 2012/10/19 06:00
MHDA- 2013/09/13 06:00
CRDT- 2012/10/19 06:00
PHST- 2012/10/19 06:00 [entrez]
PHST- 2012/10/19 06:00 [pubmed]
PHST- 2013/09/13 06:00 [medline]
AID - DN/JST.JSTAGE/jat/14936 [pii]
AID - 10.5551/jat.14936 [doi]
PST - ppublish
SO  - J Atheroscler Thromb. 2013;20(2):195-203. doi: 10.5551/jat.14936. Epub 2012 Oct 
      17.