PMID- 23076328
OWN - NLM
STAT- MEDLINE
DCOM- 20140102
LR  - 20220321
IS  - 2150-5608 (Electronic)
IS  - 2150-5594 (Print)
IS  - 2150-5594 (Linking)
VI  - 3
IP  - 7
DP  - 2012 Nov 15
TI  - The role of dendritic cells in the innate recognition of pathogenic fungi (A. 
      fumigatus, C. neoformans and C. albicans).
PG  - 635-46
LID - 10.4161/viru.22295 [doi]
AB  - Dendritic cells (DCs) are the bridge between the innate and adaptive immune 
      system. DCs are responsible for sensing and patrolling the environment, 
      initiating a host response and instructing the proper adaptive immune response 
      against pathogens. Recent advances in medical treatments have led to increased 
      use of immunosuppressive drugs, leading to the emergence of fungal species that 
      cause life-threatening infections in humans. Three of these opportunistic fungal 
      pathogens: Aspergillus fumigatus, Candida albicans and Cryptococcus neoformans 
      pose the biggest concern for the immune-compromised host. Here we will review the 
      interactions between DCs and these fungal pathogens, the receptors expressed on 
      DCs that mediate these responses and the signaling mechanisms that shape the 
      adaptive host response.
FAU - Ramirez-Ortiz, Zaida G
AU  - Ramirez-Ortiz ZG
AD  - Center for Immunology and Inflammatory Diseases and Division of Rheumatology, 
      Allergy, and Immunology, Massachusetts General Hospital and Harvard Medical 
      School, Charlestown, MA, USA.
FAU - Means, Terry K
AU  - Means TK
LA  - eng
GR  - R01 AI084884/AI/NIAID NIH HHS/United States
GR  - T32 AI007061/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20121017
PL  - United States
TA  - Virulence
JT  - Virulence
JID - 101531386
SB  - IM
MH  - Aspergillosis/immunology/microbiology
MH  - Aspergillus fumigatus/*immunology
MH  - Candida albicans/*immunology
MH  - Candidiasis/immunology/microbiology
MH  - Cryptococcosis/immunology/microbiology
MH  - Cryptococcus neoformans/*immunology
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Immunocompromised Host
PMC - PMC3545945
OTO - NOTNLM
OT  - Toll-like receptors
OT  - conventional dendritic cells
OT  - fungi
OT  - plasmacytoid dendritic cells
OT  - scavenger receptors
EDAT- 2012/10/19 06:00
MHDA- 2014/01/03 06:00
PMCR- 2012/11/15
CRDT- 2012/10/19 06:00
PHST- 2012/10/19 06:00 [entrez]
PHST- 2012/10/19 06:00 [pubmed]
PHST- 2014/01/03 06:00 [medline]
PHST- 2012/11/15 00:00 [pmc-release]
AID - 22295 [pii]
AID - 2012VIRULENCE0016R [pii]
AID - 10.4161/viru.22295 [doi]
PST - ppublish
SO  - Virulence. 2012 Nov 15;3(7):635-46. doi: 10.4161/viru.22295. Epub 2012 Oct 17.