PMID- 23076338
OWN - NLM
STAT- MEDLINE
DCOM- 20130419
LR  - 20121120
IS  - 1468-2044 (Electronic)
IS  - 0003-9888 (Linking)
VI  - 97
IP  - 12
DP  - 2012 Dec
TI  - Gain in lung function after weight reduction in severely obese children.
PG  - 1039-42
LID - 10.1136/archdischild-2011-301304 [doi]
AB  - AIM: The primary objective of this prospective cohort study was to determine the 
      effect of weight loss on pulmonary function values in extremely obese children. 
      METHODS: Obese children participated in a 26-week in-hospital or outpatient 
      multidisciplinary treatment programme. Waist circumference was measured and 
      pulmonary function tests were performed at enrolment and after 6 months. RESULTS: 
      The data of 112 children were analysed. The children had a mean age of 14.4 
      (range 8.5-18.9) years and 62.5% were girls. The mean SD score-body mass index 
      (SDS-BMI) was +3.38 at baseline and +2.91 after the intervention. Lung function 
      improved significantly: functional vital capacity increased by 3.08% (95% CI 
      1.16% to 5.00%) of the predicted value, forced expiratory volume in 1 s (FEV(1)) 
      by 2.91% (95% CI 1.11% to 4.71%) of the predicted value, total lung capacity by 
      2.27% (95% CI 1.16% to 5.00%) of the predicted value, and expiratory reserve 
      volume (ERV) by 14.8% (95% CI 8.66% to 20.88%) of the predicted value. The 
      increase in ERV correlated with the reduction in SDS-BMI and with the reduction 
      in waist circumference. FEV(1) did not correlate with the reduction in either 
      SDS-BMI or waist circumference. CONCLUSIONS: Weight loss in severely obese 
      children correlated with an improvement in lung function, especially ERV. The 
      improvement in ERV correlated with the decrease in SDS-BMI and waist 
      circumference.
FAU - van de Griendt, E J
AU  - van de Griendt EJ
AD  - Department of Pediatric Respiratory Medicine and Allergy, Emma Children's 
      Hospital, Academic Medical Centre, Amsterdam, The Netherlands. 
      e.j.vandegriendt@amc.nl
FAU - van der Baan-Slootweg, O H
AU  - van der Baan-Slootweg OH
FAU - van Essen-Zandvliet, E E M
AU  - van Essen-Zandvliet EE
FAU - van der Palen, J
AU  - van der Palen J
FAU - Tamminga-Smeulders, C L J
AU  - Tamminga-Smeulders CL
FAU - Benninga, M A
AU  - Benninga MA
FAU - van Aalderen, W M C
AU  - van Aalderen WM
LA  - eng
PT  - Journal Article
DEP - 20121016
PL  - England
TA  - Arch Dis Child
JT  - Archives of disease in childhood
JID - 0372434
SB  - IM
MH  - Adolescent
MH  - Body Mass Index
MH  - Child
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Lung/*physiopathology
MH  - Male
MH  - Obesity, Morbid/*physiopathology/therapy
MH  - Prospective Studies
MH  - Pulmonary Ventilation
MH  - Respiratory Function Tests
MH  - Weight Loss/*physiology
EDAT- 2012/10/19 06:00
MHDA- 2013/04/23 06:00
CRDT- 2012/10/19 06:00
PHST- 2012/10/19 06:00 [entrez]
PHST- 2012/10/19 06:00 [pubmed]
PHST- 2013/04/23 06:00 [medline]
AID - archdischild-2011-301304 [pii]
AID - 10.1136/archdischild-2011-301304 [doi]
PST - ppublish
SO  - Arch Dis Child. 2012 Dec;97(12):1039-42. doi: 10.1136/archdischild-2011-301304. 
      Epub 2012 Oct 16.