PMID- 23076685
OWN - NLM
STAT- MEDLINE
DCOM- 20130806
LR  - 20211021
IS  - 1436-2813 (Electronic)
IS  - 0941-1291 (Linking)
VI  - 43
IP  - 3
DP  - 2013 Mar
TI  - Surgery for a gastroenteropancreatic neuroendocrine tumor (GEPNET) in multiple 
      endocrine neoplasia type 1.
PG  - 229-36
LID - 10.1007/s00595-012-0376-5 [doi]
AB  - Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominantly inherited 
      endocrine tumor syndrome characterized by tumor development in various endocrine 
      organs such as the parathyroid, endocrine pancreas, anterior pituitary and 
      adrenal cortex. The first extensive database for Asian patients with MEN1 was 
      established by the MEN Consortium of Japan. Although the clinical features of 
      Japanese patients with MEN1 are similar to those from Western countries, there 
      are several characteristic differences between them. In particular, 
      gastroenteropancreatic neuroendocrine tumor (GEPNET) is seen in approximately 
      60 % of patients with MEN1 in Japan. Although its development is the strongest 
      prognostic factor in patients with MEN1, the characteristics of MEN1-associated 
      GEPNET still remain unclear. This is especially true for the differences in 
      clinical features of GEPNET with and without MEN1. Improved long-term survival is 
      obtained by curative surgery for patients with MEN1-associated GEPNET. The 
      current surgical indications are expanding even in patients with hepatic 
      metastases because of the improved surgical outcome. This article reviews the 
      clinical characteristics in these patients with a particular focus on surgery, 
      diagnosis, surgical indications, surgical method, and surgical outcome.
FAU - Hanazaki, Kazuhiro
AU  - Hanazaki K
AD  - Department of Surgery, Kochi Medical School, Kochi University, Kohasu, Okocho, 
      Nankoku, Kochi, 783-8505, Japan. hanazaki@kochi-u.ac.jp
FAU - Sakurai, Akihiro
AU  - Sakurai A
FAU - Munekage, Masaya
AU  - Munekage M
FAU - Ichikawa, Kengo
AU  - Ichikawa K
FAU - Namikawa, Tsutomu
AU  - Namikawa T
FAU - Okabayashi, Takehiro
AU  - Okabayashi T
FAU - Imamura, Masayuki
AU  - Imamura M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20121019
PL  - Japan
TA  - Surg Today
JT  - Surgery today
JID - 9204360
SB  - IM
MH  - Digestive System Surgical Procedures/*methods
MH  - Humans
MH  - Multiple Endocrine Neoplasia Type 1/*surgery
MH  - Neuroendocrine Tumors/*surgery
MH  - Pancreatic Neoplasms/*surgery
MH  - Stomach Neoplasms/*surgery
EDAT- 2012/10/19 06:00
MHDA- 2013/08/07 06:00
CRDT- 2012/10/19 06:00
PHST- 2012/03/14 00:00 [received]
PHST- 2012/04/09 00:00 [accepted]
PHST- 2012/10/19 06:00 [entrez]
PHST- 2012/10/19 06:00 [pubmed]
PHST- 2013/08/07 06:00 [medline]
AID - 10.1007/s00595-012-0376-5 [doi]
PST - ppublish
SO  - Surg Today. 2013 Mar;43(3):229-36. doi: 10.1007/s00595-012-0376-5. Epub 2012 Oct 
      19.