PMID- 23077981
OWN - NLM
STAT- MEDLINE
DCOM- 20130417
LR  - 20220330
IS  - 1469-0691 (Electronic)
IS  - 1198-743X (Linking)
VI  - 18
IP  - 12
DP  - 2012 Dec
TI  - Immediate and long-term outcome of left-sided infective endocarditis. A 12-year 
      prospective study from a contemporary cohort in a referral hospital.
PG  - E522-30
LID - 10.1111/1469-0691.12033 [doi]
AB  - The aim of this study was to describe the immediate and long-term prognosis of a 
      contemporary cohort of patients with left-sided infective endocarditis (LSIE). A 
      prospective observational cohort study was conducted in a referral centre. 
      Between January 2000 and December 2011, all consecutive adult patients with LSIE 
      were followed-up until death, relapse, recurrence, need for late surgery, or last 
      control. During the active phase of IE, 174 of 438 patients underwent surgery 
      (40% overall; 43% native valve (NVIE), 30% prosthetic valve (PVIE)) and 125 died 
      (29% overall; 26% NVIE, 39% PVIE). The median follow-up in survivors was 3.2 
      years (interquartile range (IQR) 1.0-6.0 years). Relapses occurred in seven 
      patients (2.2%; 95% CI, 1.1-4.5) and recurrences in eight (2.6%; 95% CI, 
      1.3-5.0), with an incidence density of 0.0067 per patient-year (95% CI, 
      0.0029-0.0133) and high mortality (75% of recurrences). Only four of 130 
      survivors (3.1%; 95% CI, 1.2-7.6) who were treated surgically during the active 
      phase of the disease, and 14/183 (7.7%; 95% CI, 4.6-12.4) of those not undergoing 
      surgery needed operation during follow-up (p 0.09). In the 313 survivors, 
      actuarial survival was 86% at 1 year (87% NVIE, 83% PVIE), 79% at 2 years (81% 
      NVIE, 72% PVIE) and 68% at 5 years (71% NVIE, 57% PVIE). At 1 year, 115 of 397 
      patients (29.0%; 95% CI, 24.7-33.6) remained alive, with no surgery requirement, 
      relapse or recurrence. LSIE is associated with considerable in-hospital and 
      long-term mortality, especially PVIE. However, relapses, recurrences and the need 
      for late surgery are uncommon.
CI  - (c) 2012 The Authors. Clinical Microbiology and Infection (c) 2012 European Society 
      of Clinical Microbiology and Infectious Diseases.
FAU - Fernandez-Hidalgo, N
AU  - Fernandez-Hidalgo N
AD  - Department of Infectious Diseases, Hospital Universitari Vall d'Hebron, 
      Barcelona, Spain. nufernan@gmail.com
FAU - Almirante, B
AU  - Almirante B
FAU - Tornos, P
AU  - Tornos P
FAU - Gonzalez-Alujas, M T
AU  - Gonzalez-Alujas MT
FAU - Planes, A M
AU  - Planes AM
FAU - Galinanes, M
AU  - Galinanes M
FAU - Pahissa, A
AU  - Pahissa A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121018
PL  - England
TA  - Clin Microbiol Infect
JT  - Clinical microbiology and infection : the official publication of the European 
      Society of Clinical Microbiology and Infectious Diseases
JID - 9516420
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Cohort Studies
MH  - Endocarditis/*epidemiology/surgery
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Recurrence
MH  - Survival Analysis
MH  - Tertiary Care Centers
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2012/10/20 06:00
MHDA- 2013/04/18 06:00
CRDT- 2012/10/20 06:00
PHST- 2012/10/20 06:00 [entrez]
PHST- 2012/10/20 06:00 [pubmed]
PHST- 2013/04/18 06:00 [medline]
AID - S1198-743X(14)60814-4 [pii]
AID - 10.1111/1469-0691.12033 [doi]
PST - ppublish
SO  - Clin Microbiol Infect. 2012 Dec;18(12):E522-30. doi: 10.1111/1469-0691.12033. 
      Epub 2012 Oct 18.