PMID- 23079232
OWN - NLM
STAT- MEDLINE
DCOM- 20130426
LR  - 20181202
IS  - 1618-095X (Electronic)
IS  - 0944-7113 (Linking)
VI  - 19
IP  - 14
DP  - 2012 Nov 15
TI  - Cognition-enhancing and neuroprotective activities of the standardized extract of 
      Betula platyphylla bark and its major diarylheptanoids.
PG  - 1315-20
LID - S0944-7113(12)00322-4 [pii]
LID - 10.1016/j.phymed.2012.09.012 [doi]
AB  - Diarylheptanoids have been the center of the intensive research efforts for 
      Alzheimer's disease and other neurodegenerative diseases. The present study aimed 
      to determine the effect of the standardized extract of B. platyphylla bark and 
      its major diarylheptanoids in scopolamine-induced amnesic mice through cyclic AMP 
      response element-binding protein (CREB) activation. Oral administration of the 
      standardized extract of B. platyphylla bark (100mg/kg body weight), aceroside 
      VIII (1mg/kg body weight) and platyphylloside (1 or 2mg/kg body weight) 
      significantly ameliorated scopolamine-induced amnesia in passive avoidance test. 
      CREB phosphorylation and brain-derived neurotrophic factor (BDNF) expression in 
      the cortex and hippocampus of the scopolamine-treated mice were markedly 
      increased by the treatment of the standardized extract of B. platyphylla bark and 
      platyphylloside. The standardized extract of B. platyphylla bark and its major 
      diarylheptanoids also significantly protected HT22 cells against neurotoxicity 
      induced by glutamate insult. The standardized extract of B. platyphylla bark and 
      platyphylloside may ameliorate memory deficits by activating the CREB-BDNF 
      pathway and prevent a neurodegeneration by inhibiting neuronal cell death.
CI  - Copyright (c) 2012 Elsevier GmbH. All rights reserved.
FAU - Lee, Ki Yong
AU  - Lee KY
AD  - College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul 
      National University, Seoul, Republic of Korea.
FAU - Jeong, Eun Ju
AU  - Jeong EJ
FAU - Huh, Jungmoo
AU  - Huh J
FAU - Cho, Namki
AU  - Cho N
FAU - Kim, Tae Bum
AU  - Kim TB
FAU - Jeon, Byung Ju
AU  - Jeon BJ
FAU - Kim, Seung Hyun
AU  - Kim SH
FAU - Kim, Hong Pyo
AU  - Kim HP
FAU - Sung, Sang Hyun
AU  - Sung SH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121015
PL  - Germany
TA  - Phytomedicine
JT  - Phytomedicine : international journal of phytotherapy and phytopharmacology
JID - 9438794
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - 0 (Diarylheptanoids)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Plant Extracts)
RN  - 3KX376GY7L (Glutamic Acid)
RN  - DL48G20X8X (Scopolamine)
SB  - IM
MH  - Administration, Oral
MH  - Amnesia/chemically induced/metabolism/*prevention & control
MH  - Animals
MH  - Avoidance Learning/drug effects
MH  - Betula/*chemistry
MH  - Brain/drug effects/metabolism
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cell Death/drug effects
MH  - Cognition/*drug effects
MH  - Cyclic AMP Response Element-Binding Protein/metabolism
MH  - Diarylheptanoids/pharmacology/*therapeutic use
MH  - Glutamic Acid
MH  - Male
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Neurodegenerative Diseases/metabolism/prevention & control
MH  - Neuroprotective Agents/pharmacology/*therapeutic use
MH  - *Phytotherapy
MH  - Plant Bark
MH  - Plant Extracts/pharmacology/*therapeutic use
MH  - Reference Standards
MH  - Scopolamine
MH  - Signal Transduction
EDAT- 2012/10/20 06:00
MHDA- 2013/04/27 06:00
CRDT- 2012/10/20 06:00
PHST- 2012/04/18 00:00 [received]
PHST- 2012/07/16 00:00 [revised]
PHST- 2012/09/06 00:00 [accepted]
PHST- 2012/10/20 06:00 [entrez]
PHST- 2012/10/20 06:00 [pubmed]
PHST- 2013/04/27 06:00 [medline]
AID - S0944-7113(12)00322-4 [pii]
AID - 10.1016/j.phymed.2012.09.012 [doi]
PST - ppublish
SO  - Phytomedicine. 2012 Nov 15;19(14):1315-20. doi: 10.1016/j.phymed.2012.09.012. 
      Epub 2012 Oct 15.