PMID- 23080167
OWN - NLM
STAT- MEDLINE
DCOM- 20130416
LR  - 20161109
IS  - 0065-2598 (Print)
IS  - 0065-2598 (Linking)
VI  - 758
DP  - 2012
TI  - Brain-derived neurotrophic factor in the nucleus tractus solitarii modulates 
      glucose homeostasis after carotid chemoreceptor stimulation in rats.
PG  - 233-9
LID - 10.1007/978-94-007-4584-1_32 [doi]
AB  - Neuronal systems, which regulate energy intake, energy expenditure and endogenous 
      glucose production, sense and respond to input from hormonal related signals that 
      convey information from body energy availability. Carotid chemoreceptors (CChr) 
      function as sensors for circulating glucose levels and contribute to glycemic 
      counterregulatory responses. Brain-derived neurotrophic factor (BDNF) that plays 
      an important role in the endocrine system to regulate glucose metabolism could 
      play a role in hyperglycemic glucose reflex with brain glucose retention (BGR) 
      evoked by anoxic CChr stimulation. Infusing BDNF into the nucleus tractus 
      solitarii (NTS) before CChr stimulation, showed that this neurotrophin increased 
      arterial glucose and BGR. In contrast, BDNF receptor (TrkB) antagonist (K252a) 
      infusions in NTS resulted in a decrease in both glucose variables.
FAU - Montero, Sergio
AU  - Montero S
AD  - Universidad de Colima, Colima, Mexico.
FAU - Cuellar, Ricardo
AU  - Cuellar R
FAU - Lemus, Monica
AU  - Lemus M
FAU - Avalos, Reyes
AU  - Avalos R
FAU - Ramirez, Gladys
AU  - Ramirez G
FAU - de Alvarez-Buylla, Elena Roces
AU  - de Alvarez-Buylla ER
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Adv Exp Med Biol
JT  - Advances in experimental medicine and biology
JID - 0121103
RN  - 0 (Blood Glucose)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - O5DDB9Z95G (Sodium Cyanide)
SB  - IM
MH  - Animals
MH  - Blood Glucose/*analysis
MH  - Brain-Derived Neurotrophic Factor/*physiology
MH  - Carotid Body/*physiology
MH  - *Homeostasis
MH  - Male
MH  - Rats
MH  - Rats, Wistar
MH  - Sodium Cyanide/pharmacology
MH  - Solitary Nucleus/*physiology
EDAT- 2012/10/20 06:00
MHDA- 2013/04/17 06:00
CRDT- 2012/10/20 06:00
PHST- 2012/10/20 06:00 [entrez]
PHST- 2012/10/20 06:00 [pubmed]
PHST- 2013/04/17 06:00 [medline]
AID - 10.1007/978-94-007-4584-1_32 [doi]
PST - ppublish
SO  - Adv Exp Med Biol. 2012;758:233-9. doi: 10.1007/978-94-007-4584-1_32.