PMID- 23082085
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121022
LR  - 20211021
IS  - 1741-4288 (Electronic)
IS  - 1741-427X (Print)
IS  - 1741-427X (Linking)
VI  - 2012
DP  - 2012
TI  - Effect of Alpinia katsumadai Hayata on House Dust Mite-Induced Atopic Dermatitis 
      in NC/Nga Mice.
PG  - 705167
LID - 10.1155/2012/705167 [doi]
LID - 705167
AB  - We evaluated the effects of Alpinia katsumadai Hayata (AKH, Zingiberaceae) 
      extract on the production of nitric oxide (NO) and prostaglandin E(2) (PGE(2)) in 
      RAW 264.7 cells, thymus- and-activation-regulated chemokine (TARC/CCL17) in HaCaT 
      cells, and histamine level in HMC-1 cells. In an in vivo experiment, atopic 
      dermatitis was induced by topical application of house dust mites for 4 weeks, 
      and the protective effects of AKH was investigated by measuring the severity of 
      the skin reaction on the back and ears, and plasma levels of immunoglobulin E 
      (IgE) and histamine. AKH extract suppressed the production of NO and PGE(2) in 
      RAW 264.7 cells, TARC in HaCaT cells, and histamine in HMC-1 cells in a 
      dose-dependent manner. In in vivo experiments, the severity of dermatitis, 
      including erythema/hemorrhage, edema, erosion and scaling, and plasma levels of 
      IgE, and histamine were lower in NC/Nga mice with atopic dermatitis, treated with 
      AKH extract than in untreated mice. AKH extract reduced the histological 
      manifestations of atopic dermatitis-like skin lesions such as erosion, 
      hyperplasia of the epidermis and dermis, and inflammatory cell infiltration on 
      the skin of the back and ear. These results suggest that AKH inhibits the 
      development of house dust mite-induced atopic dermatitis in NC/Nga mice.
FAU - Lim, Hye-Sun
AU  - Lim HS
AD  - Basic Herbal Medicine Research Group, Korea Institute of Oriental Medicine, 
      Daejeon 305-811, Republic of Korea.
FAU - Seo, Chang-Seob
AU  - Seo CS
FAU - Ha, Hyekyung
AU  - Ha H
FAU - Lee, Hoyoung
AU  - Lee H
FAU - Lee, Jun Kyung
AU  - Lee JK
FAU - Lee, Mee-Young
AU  - Lee MY
FAU - Shin, Hyeunkyoo
AU  - Shin H
LA  - eng
PT  - Journal Article
DEP - 20121002
PL  - United States
TA  - Evid Based Complement Alternat Med
JT  - Evidence-based complementary and alternative medicine : eCAM
JID - 101215021
PMC - PMC3467941
EDAT- 2012/10/20 06:00
MHDA- 2012/10/20 06:01
PMCR- 2012/10/02
CRDT- 2012/10/20 06:00
PHST- 2012/06/26 00:00 [received]
PHST- 2012/08/31 00:00 [revised]
PHST- 2012/09/04 00:00 [accepted]
PHST- 2012/10/20 06:00 [entrez]
PHST- 2012/10/20 06:00 [pubmed]
PHST- 2012/10/20 06:01 [medline]
PHST- 2012/10/02 00:00 [pmc-release]
AID - 10.1155/2012/705167 [doi]
PST - ppublish
SO  - Evid Based Complement Alternat Med. 2012;2012:705167. doi: 10.1155/2012/705167. 
      Epub 2012 Oct 2.