PMID- 2308230 OWN - NLM STAT- MEDLINE DCOM- 19900410 LR - 20220408 IS - 0047-1860 (Print) IS - 0047-1860 (Linking) VI - 38 IP - 1 DP - 1990 Jan TI - [Clinical reference values for laboratory hematology tests calculated using the iterative truncation method with correction: Part 1. Reference values for erythrocyte count, hemoglobin quantity, hematocrit and other erythrocyte parameters including MCV, MCH, MCHC and RDW]. PG - 93-103 AB - Age and sex dependent differences in the clinical reference values for erythrocyte count (RBC), hemoglobin quantity (Hb), hematocrit (Ht) and other erythrocyte parameters including MCV (mean corpuscular volume), MCH (mean corpuscular hemoglobin), MCHC (mean corpuscular hemoglobin concentration) and RDW (red cell distribution width), were calculated by the iterative truncation method with correction (Usui's method) using the results from tests on 6,300 patients' specimens obtained at Kyoto University Hospital. For RBC, Hb and Ht, the data obtained from the individuals below 13 years old showed the normal or sometimes log-normal distribution, but adjustment by the Xn-type variable transformation was often necessary to obtain the normal distribution for the data taken from the populations containing individuals over the age of 14. For the clinical reference values of RBC, Hb and Ht, no sex difference was observed below the age of 12. The values for males were significantly higher than those of females in the age range 13-79, and the values showed no significant sex-dependent difference at ages above 80. In females, age-dependent change of values for RBC, Hb and Ht was less prominent than in males; especially the upper limit values for females were very stable for all ages. MCV and MCH gradually increased with age both in males and females, and the MCHC remained constant in all age populations of male and female. The reference value for RDW was generated by the percentile method instead of the iterative truncation method because of the strong deviation in the distribution pattern, and the RDW values showed a gradual increase with age in both males and females. FAU - Shiga, S AU - Shiga S AD - Hematology Division of Central Clinical Laboratory, Kyoto University Hospital. FAU - Koyanagi, I AU - Koyanagi I FAU - Kannagi, R AU - Kannagi R LA - jpn PT - English Abstract PT - Journal Article PL - Japan TA - Rinsho Byori JT - Rinsho byori. The Japanese journal of clinical pathology JID - 2984781R SB - IM MH - Age Factors MH - Blood Volume MH - Erythrocyte Count MH - Erythrocyte Indices MH - Female MH - Hematocrit MH - *Hematologic Tests/statistics & numerical data MH - Hemoglobinometry MH - Humans MH - Male MH - Reference Values MH - Sex Factors EDAT- 1990/01/01 00:00 MHDA- 1990/01/01 00:01 CRDT- 1990/01/01 00:00 PHST- 1990/01/01 00:00 [pubmed] PHST- 1990/01/01 00:01 [medline] PHST- 1990/01/01 00:00 [entrez] PST - ppublish SO - Rinsho Byori. 1990 Jan;38(1):93-103.