PMID- 23082321
OWN - NLM
STAT- MEDLINE
DCOM- 20121119
LR  - 20211021
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 32
IP  - 34
DP  - 2012 Aug 22
TI  - A calorie-restricted diet decreases brain iron accumulation and preserves motor 
      performance in old rhesus monkeys.
PG  - 11897-904
AB  - Caloric restriction (CR) reduces the pathological effects of aging and extends 
      the lifespan in many species, including nonhuman primates, although the effect on 
      the brain is less well characterized. We used two common indicators of aging, 
      motor performance speed and brain iron deposition measured in vivo using magnetic 
      resonance imaging, to determine the potential effect of CR on elderly rhesus 
      macaques eating restricted (n=24, 13 males, 11 females) and standard (n=17, 8 
      males, 9 females) diets. Both the CR and control monkeys showed age-related 
      increases in iron concentrations in globus pallidus (GP) and substantia nigra 
      (SN), although the CR group had significantly less iron deposition in the GP, SN, 
      red nucleus, and temporal cortex. A Diet X Age interaction revealed that CR 
      modified age-related brain changes, evidenced as attenuation in the rate of iron 
      accumulation in basal ganglia and parietal, temporal, and perirhinal cortex. 
      Additionally, control monkeys had significantly slower fine motor performance on 
      the Movement Assessment Panel, which was negatively correlated with iron 
      accumulation in left SN and parietal lobe, although CR animals did not show this 
      relationship. Our observations suggest that the CR-induced benefit of reduced 
      iron deposition and preserved motor function may indicate neural protection 
      similar to effects described previously in aging rodent and primate species.
FAU - Kastman, Erik K
AU  - Kastman EK
AD  - Geriatric Research Education and Clinical Center, Wm. S. Middleton Memorial 
      Veterans Hospital, Madison, Wisconsin 53705, USA.
FAU - Willette, Auriel A
AU  - Willette AA
FAU - Coe, Christopher L
AU  - Coe CL
FAU - Bendlin, Barbara B
AU  - Bendlin BB
FAU - Kosmatka, Kris J
AU  - Kosmatka KJ
FAU - McLaren, Donald G
AU  - McLaren DG
FAU - Xu, Guofan
AU  - Xu G
FAU - Canu, Elisa
AU  - Canu E
FAU - Field, Aaron S
AU  - Field AS
FAU - Alexander, Andrew L
AU  - Alexander AL
FAU - Voytko, Mary Lou
AU  - Voytko ML
FAU - Beasley, T Mark
AU  - Beasley TM
FAU - Colman, Ricki J
AU  - Colman RJ
FAU - Weindruch, Richard H
AU  - Weindruch RH
FAU - Johnson, Sterling C
AU  - Johnson SC
LA  - eng
GR  - R01 AG043125/AG/NIA NIH HHS/United States
GR  - RR020141-01/RR/NCRR NIH HHS/United States
GR  - P01 AG11915/AG/NIA NIH HHS/United States
GR  - AG000213/AG/NIA NIH HHS/United States
GR  - T32 AG000213/AG/NIA NIH HHS/United States
GR  - P01 AG011915/AG/NIA NIH HHS/United States
GR  - C06 RR020141/RR/NCRR NIH HHS/United States
GR  - C06 RR015459/RR/NCRR NIH HHS/United States
GR  - P51 RR000167/RR/NCRR NIH HHS/United States
GR  - RR15459-01/RR/NCRR NIH HHS/United States
PT  - Corrected and Republished Article
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - E1UOL152H7 (Iron)
SB  - IM
CRF - J Neurosci. 2010 Jun 9;30(23):7940-7. PMID: 20534842
MH  - Aging
MH  - Animals
MH  - Brain/*metabolism
MH  - *Brain Mapping
MH  - *Caloric Restriction
MH  - Eating/physiology
MH  - Electronic Data Processing
MH  - Female
MH  - Image Processing, Computer-Assisted
MH  - Iron/blood/*metabolism
MH  - Macaca mulatta
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Multivariate Analysis
MH  - Psychomotor Performance/*physiology
MH  - Statistics as Topic
PMC - PMC3548565
MID - NIHMS403452
EDAT- 2012/10/20 06:00
MHDA- 2012/12/10 06:00
PMCR- 2013/02/22
CRDT- 2012/10/20 06:00
PHST- 2012/10/20 06:00 [entrez]
PHST- 2012/10/20 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
PHST- 2013/02/22 00:00 [pmc-release]
AID - 3786630 [pii]
AID - 10.1523/jneurosci.2553-12.2012 [doi]
PST - ppublish
SO  - J Neurosci. 2012 Aug 22;32(34):11897-904. doi: 10.1523/jneurosci.2553-12.2012.