PMID- 23084083
OWN - NLM
STAT- MEDLINE
DCOM- 20130801
LR  - 20220331
IS  - 1558-1497 (Electronic)
IS  - 0197-4580 (Linking)
VI  - 34
IP  - 4
DP  - 2013 Apr
TI  - Age effect on the default mode network, inner thoughts, and cognitive abilities.
PG  - 1292-301
LID - S0197-4580(12)00454-X [pii]
LID - 10.1016/j.neurobiolaging.2012.08.018 [doi]
AB  - Age-related effects on the default mode network (DMN) connectivity as measured at 
      rest using functional magnetic resonance imaging (fMRI) are now well described. 
      Little is known however about the relationships between these changes and 
      age-related effects on cognition or on the unconstrained thoughts which occur 
      during the resting-state scan, called inner experience. Brain resting-state 
      activity, inner experience, and cognitive ability measurements were obtained in 
      70 participants aged 19-80 years. The anterior-posterior disruption of DMN 
      activity with age reported in previous studies was recovered here. A significant 
      effect of age was also found on cognitive abilities but not on inner experience. 
      Finally, age-related changes in DMN connectivity were found to correlate with 
      cognitive abilities, and more specifically with autobiographical memory 
      performance. These findings provide new information to fuel the debate on the 
      role of the brain default mode and more specifically on the effect of age-related 
      changes in resting-state activity as measured with fMRI.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Mevel, Katell
AU  - Mevel K
AD  - INSERM, U1077 Caen, France.
FAU - Landeau, Brigitte
AU  - Landeau B
FAU - Fouquet, Marine
AU  - Fouquet M
FAU - La Joie, Renaud
AU  - La Joie R
FAU - Villain, Nicolas
AU  - Villain N
FAU - Mezenge, Florence
AU  - Mezenge F
FAU - Perrotin, Audrey
AU  - Perrotin A
FAU - Eustache, Francis
AU  - Eustache F
FAU - Desgranges, Beatrice
AU  - Desgranges B
FAU - Chetelat, Gael
AU  - Chetelat G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121018
PL  - United States
TA  - Neurobiol Aging
JT  - Neurobiology of aging
JID - 8100437
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aging/*physiology
MH  - Brain/*physiology
MH  - Cognition/*physiology
MH  - Cognitive Reserve/*physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nerve Net/*physiology
MH  - Thinking/*physiology
MH  - Young Adult
EDAT- 2012/10/23 06:00
MHDA- 2013/08/02 06:00
CRDT- 2012/10/23 06:00
PHST- 2012/04/23 00:00 [received]
PHST- 2012/08/15 00:00 [revised]
PHST- 2012/08/28 00:00 [accepted]
PHST- 2012/10/23 06:00 [entrez]
PHST- 2012/10/23 06:00 [pubmed]
PHST- 2013/08/02 06:00 [medline]
AID - S0197-4580(12)00454-X [pii]
AID - 10.1016/j.neurobiolaging.2012.08.018 [doi]
PST - ppublish
SO  - Neurobiol Aging. 2013 Apr;34(4):1292-301. doi: 
      10.1016/j.neurobiolaging.2012.08.018. Epub 2012 Oct 18.