PMID- 23084292
OWN - NLM
STAT- MEDLINE
DCOM- 20130114
LR  - 20221207
IS  - 1537-6605 (Electronic)
IS  - 0002-9297 (Print)
IS  - 0002-9297 (Linking)
VI  - 91
IP  - 5
DP  - 2012 Nov 2
TI  - Unraveling multiple MHC gene associations with systemic lupus erythematosus: 
      model choice indicates a role for HLA alleles and non-HLA genes in Europeans.
PG  - 778-93
LID - S0002-9297(12)00467-3 [pii]
LID - 10.1016/j.ajhg.2012.08.026 [doi]
AB  - We have performed a meta-analysis of the major-histocompatibility-complex (MHC) 
      region in systemic lupus erythematosus (SLE) to determine the association with 
      both SNPs and classical human-leukocyte-antigen (HLA) alleles. More specifically, 
      we combined results from six studies and well-known out-of-study control data 
      sets, providing us with 3,701 independent SLE cases and 12,110 independent 
      controls of European ancestry. This study used genotypes for 7,199 SNPs within 
      the MHC region and for classical HLA alleles (typed and imputed). Our results 
      from conditional analysis and model choice with the use of the Bayesian 
      information criterion show that the best model for SLE association includes both 
      classical loci (HLA-DRB1( *)03:01, HLA-DRB1( *)08:01, and HLA-DQA1( *)01:02) and two 
      SNPs, rs8192591 (in class III and upstream of NOTCH4) and rs2246618 (MICB in 
      class I). Our approach was to perform a stepwise search from multiple baseline 
      models deduced from a priori evidence on HLA-DRB1 lupus-associated alleles, a 
      stepwise regression on SNPs alone, and a stepwise regression on HLA alleles. With 
      this approach, we were able to identify a model that was an overwhelmingly better 
      fit to the data than one identified by simple stepwise regression either on SNPs 
      alone (Bayes factor [BF] > 50) or on classical HLA alleles alone (BF > 1,000).
CI  - Copyright (c) 2012 The American Society of Human Genetics. Published by Elsevier 
      Inc. All rights reserved.
FAU - Morris, David L
AU  - Morris DL
AD  - Divisions of Genetics and Molecular Medicine and Immunology, Infection and 
      Inflammatory Disease, King's College London, London, UK.
FAU - Taylor, Kimberly E
AU  - Taylor KE
FAU - Fernando, Michelle M A
AU  - Fernando MM
FAU - Nititham, Joanne
AU  - Nititham J
FAU - Alarcon-Riquelme, Marta E
AU  - Alarcon-Riquelme ME
FAU - Barcellos, Lisa F
AU  - Barcellos LF
FAU - Behrens, Timothy W
AU  - Behrens TW
FAU - Cotsapas, Chris
AU  - Cotsapas C
FAU - Gaffney, Patrick M
AU  - Gaffney PM
FAU - Graham, Robert R
AU  - Graham RR
FAU - Pons-Estel, Bernardo A
AU  - Pons-Estel BA
FAU - Gregersen, Peter K
AU  - Gregersen PK
FAU - Harley, John B
AU  - Harley JB
FAU - Hauser, Stephen L
AU  - Hauser SL
FAU - Hom, Geoffrey
AU  - Hom G
CN  - International MHC and Autoimmunity Genetics Network
FAU - Langefeld, Carl D
AU  - Langefeld CD
FAU - Noble, Janelle A
AU  - Noble JA
FAU - Rioux, John D
AU  - Rioux JD
FAU - Seldin, Michael F
AU  - Seldin MF
CN  - Systemic Lupus Erythematosus Genetics Consortium
FAU - Criswell, Lindsey A
AU  - Criswell LA
FAU - Vyse, Timothy J
AU  - Vyse TJ
LA  - eng
GR  - P60 AR053308/AR/NIAMS NIH HHS/United States
GR  - 5R01ES011740/ES/NIEHS NIH HHS/United States
GR  - 3P50CA093459/CA/NCI NIH HHS/United States
GR  - 18239/ARC_/Arthritis Research UK/United Kingdom
GR  - 5P50CA097007/CA/NCI NIH HHS/United States
GR  - R37 AI024717/AI/NIAID NIH HHS/United States
GR  - P01 AI083194/AI/NIAID NIH HHS/United States
GR  - U19 AI067152/AI/NIAID NIH HHS/United States
GR  - R01 AI024717/AI/NIAID NIH HHS/United States
GR  - 5R01CA133996/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, N.I.H., Extramural
DEP - 20121018
PL  - United States
TA  - Am J Hum Genet
JT  - American journal of human genetics
JID - 0370475
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
RN  - 0 (HLA-DQ alpha-Chains)
RN  - 0 (HLA-DQA1 antigen)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
EIN - Am J Hum Genet. 2015 Sep 3;97(3):501
MH  - *Alleles
MH  - Gene Expression Profiling
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA Antigens/*genetics
MH  - HLA-B Antigens/genetics
MH  - HLA-C Antigens/genetics
MH  - HLA-DQ alpha-Chains/genetics
MH  - HLA-DRB1 Chains/genetics
MH  - Haplotypes
MH  - Humans
MH  - Lupus Erythematosus, Systemic/*genetics
MH  - Major Histocompatibility Complex/*genetics
MH  - Polymorphism, Single Nucleotide
MH  - White People/*genetics
PMC - PMC3487133
FIR - Rioux, John D
IR  - Rioux JD
FIR - Goyette, Philippe
IR  - Goyette P
FIR - Vyse, Timothy J
IR  - Vyse TJ
FIR - Hammarstrom, Lennart
IR  - Hammarstrom L
FIR - Fernando, Michelle M A
IR  - Fernando MM
FIR - Green, Todd
IR  - Green T
FIR - De Jager, Philip L
IR  - De Jager PL
FIR - Foisy, Sylvain
IR  - Foisy S
FIR - Wang, Joanne
IR  - Wang J
FIR - de Bakker, Paul I W
IR  - de Bakker PI
FIR - Leslie, Stephen
IR  - Leslie S
FIR - McVean, Gilean
IR  - McVean G
FIR - Padyukov, Leonid
IR  - Padyukov L
FIR - Alfredsson, Lars
IR  - Alfredsson L
FIR - Annese, Vito
IR  - Annese V
FIR - Hafler, David A
IR  - Hafler DA
FIR - Pan-Hammarstrom, Qiang
IR  - Pan-Hammarstrom Q
FIR - Matell, Ritva
IR  - Matell R
FIR - Sawcer, Stephen J
IR  - Sawcer SJ
FIR - Compston, Alastair D
IR  - Compston AD
FIR - Cree, Bruce A C
IR  - Cree BA
FIR - Mirel, Daniel B
IR  - Mirel DB
FIR - Daly, Mark J
IR  - Daly MJ
FIR - Behrens, Tim W
IR  - Behrens TW
FIR - Klareskog, Lars
IR  - Klareskog L
FIR - Gregersen, Peter K
IR  - Gregersen PK
FIR - Oksenberg, Jorge R
IR  - Oksenberg JR
FIR - Hauser, Stephen L
IR  - Hauser SL
FIR - Harley, John B
IR  - Harley JB
FIR - Alarcon-Riquelme, Marta E
IR  - Alarcon-Riquelme ME
FIR - Criswell, Lindsey A
IR  - Criswell LA
FIR - Jacob, Chaim O
IR  - Jacob CO
FIR - Kimberly, Robert P
IR  - Kimberly RP
FIR - Moser, Kathy L
IR  - Moser KL
FIR - Tsao, Betty P
IR  - Tsao BP
FIR - Vyse, Timothy J
IR  - Vyse TJ
FIR - Langefeld, Carl D
IR  - Langefeld CD
EDAT- 2012/10/23 06:00
MHDA- 2013/01/15 06:00
PMCR- 2013/05/02
CRDT- 2012/10/23 06:00
PHST- 2012/05/04 00:00 [received]
PHST- 2012/06/26 00:00 [revised]
PHST- 2012/08/24 00:00 [accepted]
PHST- 2012/10/23 06:00 [entrez]
PHST- 2012/10/23 06:00 [pubmed]
PHST- 2013/01/15 06:00 [medline]
PHST- 2013/05/02 00:00 [pmc-release]
AID - S0002-9297(12)00467-3 [pii]
AID - AJHG1255 [pii]
AID - 10.1016/j.ajhg.2012.08.026 [doi]
PST - ppublish
SO  - Am J Hum Genet. 2012 Nov 2;91(5):778-93. doi: 10.1016/j.ajhg.2012.08.026. Epub 
      2012 Oct 18.